Influence of freezing (THERMAL) profiles on the morphology and mechanical properties of poly (l-lactic acid) scaffolds

Harish Chinnasami, Frank Breeden, Daniel Hayes, Ram Devireddy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Bio-degradable Poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermal liquid-liquid phase separation method. A solution of PLLA-Dioxane was prepared by dissolving PLLA in dehydrated 1, 4-Dioxane. This PLLA-Dioxane solution was then directionally frozen in vials of similar dimensions but made of different materials (borosilicate glass, aluminum and copper). The frozen solution was then placed in a freeze-dryer to allow for the frozen dioxane to sublimate or lyophilized. The porosities of the resulting PLLA scaffolds were calculated and their porous structures were studied and compared between the three different vials (and the corresponding cooling rates).

Original languageEnglish (US)
Title of host publicationASME 2012 Summer Bioengineering Conference, SBC 2012
Pages617-618
Number of pages2
DOIs
StatePublished - Dec 1 2012
EventASME 2012 Summer Bioengineering Conference, SBC 2012 - Fajardo, Puerto Rico
Duration: Jun 20 2012Jun 23 2012

Publication series

NameASME 2012 Summer Bioengineering Conference, SBC 2012

Other

OtherASME 2012 Summer Bioengineering Conference, SBC 2012
CountryPuerto Rico
CityFajardo
Period6/20/126/23/12

Fingerprint

Lactic acid
Scaffolds
Freezing
Lactic Acid
Mechanical properties
Mercuric Chloride
Driers (materials)
Borosilicate glass
Liquids
Aluminum
Phase separation
Copper
Porosity
Cooling
1,4-dioxane

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Chinnasami, H., Breeden, F., Hayes, D., & Devireddy, R. (2012). Influence of freezing (THERMAL) profiles on the morphology and mechanical properties of poly (l-lactic acid) scaffolds. In ASME 2012 Summer Bioengineering Conference, SBC 2012 (pp. 617-618). (ASME 2012 Summer Bioengineering Conference, SBC 2012). https://doi.org/10.1115/SBC2012-80119
Chinnasami, Harish ; Breeden, Frank ; Hayes, Daniel ; Devireddy, Ram. / Influence of freezing (THERMAL) profiles on the morphology and mechanical properties of poly (l-lactic acid) scaffolds. ASME 2012 Summer Bioengineering Conference, SBC 2012. 2012. pp. 617-618 (ASME 2012 Summer Bioengineering Conference, SBC 2012).
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abstract = "Bio-degradable Poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermal liquid-liquid phase separation method. A solution of PLLA-Dioxane was prepared by dissolving PLLA in dehydrated 1, 4-Dioxane. This PLLA-Dioxane solution was then directionally frozen in vials of similar dimensions but made of different materials (borosilicate glass, aluminum and copper). The frozen solution was then placed in a freeze-dryer to allow for the frozen dioxane to sublimate or lyophilized. The porosities of the resulting PLLA scaffolds were calculated and their porous structures were studied and compared between the three different vials (and the corresponding cooling rates).",
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Chinnasami, H, Breeden, F, Hayes, D & Devireddy, R 2012, Influence of freezing (THERMAL) profiles on the morphology and mechanical properties of poly (l-lactic acid) scaffolds. in ASME 2012 Summer Bioengineering Conference, SBC 2012. ASME 2012 Summer Bioengineering Conference, SBC 2012, pp. 617-618, ASME 2012 Summer Bioengineering Conference, SBC 2012, Fajardo, Puerto Rico, 6/20/12. https://doi.org/10.1115/SBC2012-80119

Influence of freezing (THERMAL) profiles on the morphology and mechanical properties of poly (l-lactic acid) scaffolds. / Chinnasami, Harish; Breeden, Frank; Hayes, Daniel; Devireddy, Ram.

ASME 2012 Summer Bioengineering Conference, SBC 2012. 2012. p. 617-618 (ASME 2012 Summer Bioengineering Conference, SBC 2012).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Chinnasami H, Breeden F, Hayes D, Devireddy R. Influence of freezing (THERMAL) profiles on the morphology and mechanical properties of poly (l-lactic acid) scaffolds. In ASME 2012 Summer Bioengineering Conference, SBC 2012. 2012. p. 617-618. (ASME 2012 Summer Bioengineering Conference, SBC 2012). https://doi.org/10.1115/SBC2012-80119