Influence of freezing (THERMAL) profiles on the morphology and mechanical properties of poly (l-lactic acid) scaffolds

Harish Chinnasami; Frank Breeden; Daniel Hayes; Ram Devireddy

doi:10.1115/SBC2012-80119

Influence of freezing (THERMAL) profiles on the morphology and mechanical properties of poly (l-lactic acid) scaffolds

Harish Chinnasami, Frank Breeden, Daniel Hayes, Ram Devireddy

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Bio-degradable Poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermal liquid-liquid phase separation method. A solution of PLLA-Dioxane was prepared by dissolving PLLA in dehydrated 1, 4-Dioxane. This PLLA-Dioxane solution was then directionally frozen in vials of similar dimensions but made of different materials (borosilicate glass, aluminum and copper). The frozen solution was then placed in a freeze-dryer to allow for the frozen dioxane to sublimate or lyophilized. The porosities of the resulting PLLA scaffolds were calculated and their porous structures were studied and compared between the three different vials (and the corresponding cooling rates).

Original language	English (US)
Title of host publication	ASME 2012 Summer Bioengineering Conference, SBC 2012
Pages	617-618
Number of pages	2
DOIs	https://doi.org/10.1115/SBC2012-80119
State	Published - Dec 1 2012
Event	ASME 2012 Summer Bioengineering Conference, SBC 2012 - Fajardo, Puerto Rico Duration: Jun 20 2012 → Jun 23 2012

Publication series

Name	ASME 2012 Summer Bioengineering Conference, SBC 2012

Other

Other	ASME 2012 Summer Bioengineering Conference, SBC 2012
Country	Puerto Rico
City	Fajardo
Period	6/20/12 → 6/23/12

All Science Journal Classification (ASJC) codes

Bioengineering

Access to Document

10.1115/SBC2012-80119

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title = "Influence of freezing (THERMAL) profiles on the morphology and mechanical properties of poly (l-lactic acid) scaffolds",

abstract = "Bio-degradable Poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermal liquid-liquid phase separation method. A solution of PLLA-Dioxane was prepared by dissolving PLLA in dehydrated 1, 4-Dioxane. This PLLA-Dioxane solution was then directionally frozen in vials of similar dimensions but made of different materials (borosilicate glass, aluminum and copper). The frozen solution was then placed in a freeze-dryer to allow for the frozen dioxane to sublimate or lyophilized. The porosities of the resulting PLLA scaffolds were calculated and their porous structures were studied and compared between the three different vials (and the corresponding cooling rates).",

author = "Harish Chinnasami and Frank Breeden and Daniel Hayes and Ram Devireddy",

year = "2012",

month = dec,

day = "1",

doi = "10.1115/SBC2012-80119",

language = "English (US)",

isbn = "9780791844809",

series = "ASME 2012 Summer Bioengineering Conference, SBC 2012",

pages = "617--618",

booktitle = "ASME 2012 Summer Bioengineering Conference, SBC 2012",

note = "ASME 2012 Summer Bioengineering Conference, SBC 2012 ; Conference date: 20-06-2012 Through 23-06-2012",

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Chinnasami, H, Breeden, F, Hayes, D & Devireddy, R 2012, Influence of freezing (THERMAL) profiles on the morphology and mechanical properties of poly (l-lactic acid) scaffolds. in ASME 2012 Summer Bioengineering Conference, SBC 2012. ASME 2012 Summer Bioengineering Conference, SBC 2012, pp. 617-618, ASME 2012 Summer Bioengineering Conference, SBC 2012, Fajardo, Puerto Rico, 6/20/12. https://doi.org/10.1115/SBC2012-80119

Influence of freezing (THERMAL) profiles on the morphology and mechanical properties of poly (l-lactic acid) scaffolds. / Chinnasami, Harish; Breeden, Frank; Hayes, Daniel; Devireddy, Ram.

ASME 2012 Summer Bioengineering Conference, SBC 2012. 2012. p. 617-618 (ASME 2012 Summer Bioengineering Conference, SBC 2012).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - Bio-degradable Poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermal liquid-liquid phase separation method. A solution of PLLA-Dioxane was prepared by dissolving PLLA in dehydrated 1, 4-Dioxane. This PLLA-Dioxane solution was then directionally frozen in vials of similar dimensions but made of different materials (borosilicate glass, aluminum and copper). The frozen solution was then placed in a freeze-dryer to allow for the frozen dioxane to sublimate or lyophilized. The porosities of the resulting PLLA scaffolds were calculated and their porous structures were studied and compared between the three different vials (and the corresponding cooling rates).

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