Influence of gut microbiota on hepatic lipogenesis and disease pathogenesis

Vishal Singh, Beng San Yeoh, James M. Ntambi, Matam Vijay-Kumar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Liver, a major metabolic organ in the human body, plays a key role in the macronutrient metabolism. Accordingly, the liver is intertwined with an array of biochemical pathways that are central in keeping energy homeostasis. Loss of this delicate balance, however, may lead to a spectrum of liver diseases such as NAFLD, NASH, fibrosis, cirrhosis and HCC. The etiology of liver disorders is often multifactorial and greatly influenced by host genetics, diet and various environmental factors. Among the environmental factors, the gut microbiota has emerged as one of the key player that can profoundly influence host metabolism. Akin to a doubleedged sword, the gut microbiota and their metabolites exert both beneficial and deleterious extra-intestinal effects to the host. As a vascular firewall that receives 70 % of blood enriched with gut-derived factors via portal vein, the liver is thus aptly placed at the crossroad between host health and disease. In this chapter, we focus on the influence of gut microbiota and their metabolites in hepatic lipogenesis and disease pathogenesis.

Original languageEnglish (US)
Title of host publicationHepatic De Novo Lipogenesis and Regulation of Metabolism
PublisherSpringer International Publishing
Pages189-209
Number of pages21
ISBN (Electronic)9783319250656
ISBN (Print)9783319250632
DOIs
StatePublished - Jan 1 2015

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Lipogenesis
Liver
Metabolites
proctolin
Metabolism
Fibrosis
Nutrition
Portal Vein
Human Body
Blood Vessels
Liver Diseases
Homeostasis
Blood
Gastrointestinal Microbiome
Health
Diet

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Singh, V., Yeoh, B. S., Ntambi, J. M., & Vijay-Kumar, M. (2015). Influence of gut microbiota on hepatic lipogenesis and disease pathogenesis. In Hepatic De Novo Lipogenesis and Regulation of Metabolism (pp. 189-209). Springer International Publishing. https://doi.org/10.1007/978-3-319-25065-6_9
Singh, Vishal ; Yeoh, Beng San ; Ntambi, James M. ; Vijay-Kumar, Matam. / Influence of gut microbiota on hepatic lipogenesis and disease pathogenesis. Hepatic De Novo Lipogenesis and Regulation of Metabolism. Springer International Publishing, 2015. pp. 189-209
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Singh, V, Yeoh, BS, Ntambi, JM & Vijay-Kumar, M 2015, Influence of gut microbiota on hepatic lipogenesis and disease pathogenesis. in Hepatic De Novo Lipogenesis and Regulation of Metabolism. Springer International Publishing, pp. 189-209. https://doi.org/10.1007/978-3-319-25065-6_9

Influence of gut microbiota on hepatic lipogenesis and disease pathogenesis. / Singh, Vishal; Yeoh, Beng San; Ntambi, James M.; Vijay-Kumar, Matam.

Hepatic De Novo Lipogenesis and Regulation of Metabolism. Springer International Publishing, 2015. p. 189-209.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Singh V, Yeoh BS, Ntambi JM, Vijay-Kumar M. Influence of gut microbiota on hepatic lipogenesis and disease pathogenesis. In Hepatic De Novo Lipogenesis and Regulation of Metabolism. Springer International Publishing. 2015. p. 189-209 https://doi.org/10.1007/978-3-319-25065-6_9