Influence of locally altered in vivo shear stress on aortic histamine-forming capacity and aortic albumin uptake

Ronald Albert Markle, Theodore M. Hollis

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Effects of locally elevated shear stresses on thoracic aortic histamine formation and transmural albumin uptake have been examined under in vivo conditions in anesthetized male, mongrel dogs. Results indicate that if endothelium remains intact, significant linear relationships exist between the shear intensity and aortic histamine-forming capacity and aortic content of fluorescein-labeled bovine serum albumin following 20 h of circulation time. These data suggest that in vivo the aortic (and endothelial) histidine decarboxylase system is sensitive to local alterations in applied shear stress, and that de novo aortic histamine synthesis is involved in mediating shear-induced increases in aortic transmural permeability.

Original languageEnglish (US)
Pages (from-to)45-57
Number of pages13
JournalJournal of Vascular Research
Volume18
Issue number1-2
DOIs
StatePublished - Jan 1 1981

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Histamine
Albumins
Histidine Decarboxylase
Bovine Serum Albumin
Fluorescein
Endothelium
Permeability
Thorax
Dogs

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

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Influence of locally altered in vivo shear stress on aortic histamine-forming capacity and aortic albumin uptake. / Markle, Ronald Albert; Hollis, Theodore M.

In: Journal of Vascular Research, Vol. 18, No. 1-2, 01.01.1981, p. 45-57.

Research output: Contribution to journalArticle

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