Influence of the dairy environment on gene expression and substrate utilization in lactic acid bacteria

Todd R. Klaenhammer, M. Andrea Azcarate-Peril, Eric Altermann, Rodolphe Barrangou

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Lactic acid bacteria (LAB) are widely used for the industrial production of fermented dairy products and form a group of related low-GC-content gram-positive bacteria. The major species used in dairy manufacturing are Lactobacillus, Lactococcus, Streptococcus, and Leuconostoc. Traditionally most are applied as starter cultures for dairy fermentations or used as probiotic cultures, delivered in dairy vehicles. The appearance of the genomes of Lactococcus lactis, Bidifobacterium longum, Lactobacillus plantarum, L. johnsonii, L. acidophilus, 2 strains of Streptococcus thermophilus, and pending completion of many draft genomic sequences, is now promoting in-depth investigation into the comparative genetic content of LAB. Moreover, whole-genome transcriptional arrays are quickly revealing critical genes/operons that are coordinately expressed and the impact of environmental factors on expression of multiple gene sets. Comparative genomics between multiple genomes is providing insights into genes that are important in metabolic, physiological, and functional roles for different LAB in the environments they inhabit, ranging from the gastrointestinal tract to milk and acidified dairy products.

Original languageEnglish (US)
JournalJournal of Nutrition
Volume137
Issue number3
StatePublished - Mar 1 2007

Fingerprint

lactic acid bacteria
Lactic Acid
dairies
Genome
Bacteria
Gene Expression
gene expression
genome
Lactobacillus johnsonii
Cultured Milk Products
Lactococcus
Streptococcus thermophilus
cultured milk starters
fermented dairy products
Leuconostoc
genomics
Lactobacillus plantarum
Lactococcus lactis
genes
Dairy Products

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Klaenhammer, T. R., Azcarate-Peril, M. A., Altermann, E., & Barrangou, R. (2007). Influence of the dairy environment on gene expression and substrate utilization in lactic acid bacteria. Journal of Nutrition, 137(3).
Klaenhammer, Todd R. ; Azcarate-Peril, M. Andrea ; Altermann, Eric ; Barrangou, Rodolphe. / Influence of the dairy environment on gene expression and substrate utilization in lactic acid bacteria. In: Journal of Nutrition. 2007 ; Vol. 137, No. 3.
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Klaenhammer, TR, Azcarate-Peril, MA, Altermann, E & Barrangou, R 2007, 'Influence of the dairy environment on gene expression and substrate utilization in lactic acid bacteria', Journal of Nutrition, vol. 137, no. 3.

Influence of the dairy environment on gene expression and substrate utilization in lactic acid bacteria. / Klaenhammer, Todd R.; Azcarate-Peril, M. Andrea; Altermann, Eric; Barrangou, Rodolphe.

In: Journal of Nutrition, Vol. 137, No. 3, 01.03.2007.

Research output: Contribution to journalArticle

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Klaenhammer TR, Azcarate-Peril MA, Altermann E, Barrangou R. Influence of the dairy environment on gene expression and substrate utilization in lactic acid bacteria. Journal of Nutrition. 2007 Mar 1;137(3).