Ingestion of transient receptor potential channel agonists attenuates exercise-induced muscle cramps

Daniel H. Craighead, Sean W. Shank, Jinger Gottschall, Dennis H. Passe, Bob Murray, Lacy Marie Alexander, William Lawrence Kenney, Jr.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: Exercise-associated muscle cramping (EAMC) is a poorly understood problem that is neuromuscular in origin. Ingestion of transient receptor potential (TRP) channel agonists has been efficacious in attenuating electrically induced muscle cramps. This study examines the effect of TRP agonist ingestion on voluntarily induced EAMC and motor function. Methods: Study 1: Thirty-nine participants completed 2 trials after ingesting TRP agonist-containing active treatment (A), or vehicle (V) control. Cramping in the triceps surae muscle was induced via voluntary isometric contraction. Study 2: After ingesting A or V, 31 participants performed kinematic and psychomotor tests of manual dexterity. Results: A increased precramp contraction duration (A, 36.9 ± 4.1 s; V, 27.8 ± 3.1 s), decreased cramp EMG area under the curve (A, 37.3 ± 7.7 %EMGmax·s; V, 77.2 ± 17.7 %EMGmax·s), increased contraction force to produce the cramp (A, 13.8 ± 1.8 kg; V, 9.9 ± 1.6 kg), and decreased postcramp soreness (A, 4.1 ± 0.3 arbitrary units (a.u.); V, 4.7 ± 0.3 a.u.). Kinematic and psychomotor tests were not affected. Discussion: TRP agonist ingestion attenuated EAMC characteristics without affecting motor function. Muscle Nerve 56: 379–385, 2017.

Original languageEnglish (US)
Pages (from-to)379-385
Number of pages7
JournalMuscle and Nerve
Volume56
Issue number3
DOIs
StatePublished - Sep 1 2017

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Transient Receptor Potential Channels
Muscle Cramp
Eating
Muscles
Biomechanical Phenomena
Isometric Contraction
Area Under Curve

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Craighead, Daniel H. ; Shank, Sean W. ; Gottschall, Jinger ; Passe, Dennis H. ; Murray, Bob ; Alexander, Lacy Marie ; Kenney, Jr., William Lawrence. / Ingestion of transient receptor potential channel agonists attenuates exercise-induced muscle cramps. In: Muscle and Nerve. 2017 ; Vol. 56, No. 3. pp. 379-385.
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abstract = "Introduction: Exercise-associated muscle cramping (EAMC) is a poorly understood problem that is neuromuscular in origin. Ingestion of transient receptor potential (TRP) channel agonists has been efficacious in attenuating electrically induced muscle cramps. This study examines the effect of TRP agonist ingestion on voluntarily induced EAMC and motor function. Methods: Study 1: Thirty-nine participants completed 2 trials after ingesting TRP agonist-containing active treatment (A), or vehicle (V) control. Cramping in the triceps surae muscle was induced via voluntary isometric contraction. Study 2: After ingesting A or V, 31 participants performed kinematic and psychomotor tests of manual dexterity. Results: A increased precramp contraction duration (A, 36.9 ± 4.1 s; V, 27.8 ± 3.1 s), decreased cramp EMG area under the curve (A, 37.3 ± 7.7 {\%}EMGmax·s; V, 77.2 ± 17.7 {\%}EMGmax·s), increased contraction force to produce the cramp (A, 13.8 ± 1.8 kg; V, 9.9 ± 1.6 kg), and decreased postcramp soreness (A, 4.1 ± 0.3 arbitrary units (a.u.); V, 4.7 ± 0.3 a.u.). Kinematic and psychomotor tests were not affected. Discussion: TRP agonist ingestion attenuated EAMC characteristics without affecting motor function. Muscle Nerve 56: 379–385, 2017.",
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Ingestion of transient receptor potential channel agonists attenuates exercise-induced muscle cramps. / Craighead, Daniel H.; Shank, Sean W.; Gottschall, Jinger; Passe, Dennis H.; Murray, Bob; Alexander, Lacy Marie; Kenney, Jr., William Lawrence.

In: Muscle and Nerve, Vol. 56, No. 3, 01.09.2017, p. 379-385.

Research output: Contribution to journalArticle

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T1 - Ingestion of transient receptor potential channel agonists attenuates exercise-induced muscle cramps

AU - Craighead, Daniel H.

AU - Shank, Sean W.

AU - Gottschall, Jinger

AU - Passe, Dennis H.

AU - Murray, Bob

AU - Alexander, Lacy Marie

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N2 - Introduction: Exercise-associated muscle cramping (EAMC) is a poorly understood problem that is neuromuscular in origin. Ingestion of transient receptor potential (TRP) channel agonists has been efficacious in attenuating electrically induced muscle cramps. This study examines the effect of TRP agonist ingestion on voluntarily induced EAMC and motor function. Methods: Study 1: Thirty-nine participants completed 2 trials after ingesting TRP agonist-containing active treatment (A), or vehicle (V) control. Cramping in the triceps surae muscle was induced via voluntary isometric contraction. Study 2: After ingesting A or V, 31 participants performed kinematic and psychomotor tests of manual dexterity. Results: A increased precramp contraction duration (A, 36.9 ± 4.1 s; V, 27.8 ± 3.1 s), decreased cramp EMG area under the curve (A, 37.3 ± 7.7 %EMGmax·s; V, 77.2 ± 17.7 %EMGmax·s), increased contraction force to produce the cramp (A, 13.8 ± 1.8 kg; V, 9.9 ± 1.6 kg), and decreased postcramp soreness (A, 4.1 ± 0.3 arbitrary units (a.u.); V, 4.7 ± 0.3 a.u.). Kinematic and psychomotor tests were not affected. Discussion: TRP agonist ingestion attenuated EAMC characteristics without affecting motor function. Muscle Nerve 56: 379–385, 2017.

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