Inherited uterine inadequacy: An alternate explanation for a portion of cases of defect

Frank Martin Ahern, Ronald C. Johnson

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A substantial amount of mental retardation runs in family lines and cannot be attributed to the action of single gene pairs or to chromosomal aberrations. It was hypothesized that one of the causes of this kind of retardation might be an inherited tendency, on the part of females in the family lines, to produce an inadequate uterine environment and hence produce a high proportion of retarded offspring. If so, one would expect sisters and aunts, as compared with brothers and uncles, of retarded propositus cases to produce a higher proportion of retarded (as well as spontaneously aborted, stillborn, or neonatal casualty) offspring. An analysis of data from Reed and Reed, Mental Retardation: A Family Study, supports the hypothesis. Implications of this finding are discussed.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalBehavior Genetics
Volume3
Issue number1
DOIs
StatePublished - Mar 1 1973

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family studies
chromosome aberrations
Intellectual Disability
defect
data analysis
Chromosome Aberrations
genes
Genes
gene
family
reed

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

Cite this

Ahern, Frank Martin ; Johnson, Ronald C. / Inherited uterine inadequacy : An alternate explanation for a portion of cases of defect. In: Behavior Genetics. 1973 ; Vol. 3, No. 1. pp. 1-12.
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Inherited uterine inadequacy : An alternate explanation for a portion of cases of defect. / Ahern, Frank Martin; Johnson, Ronald C.

In: Behavior Genetics, Vol. 3, No. 1, 01.03.1973, p. 1-12.

Research output: Contribution to journalArticle

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