Inhibition by Dietary Organoselenium, P-Methoxybenzene-Selenol, of Hepatocarcinogenesis Induced by Azoxymethane in Rats*1

Takuji Tanaka, Bandaru S. Reddy, Karam El-Bayoumy

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The effect of dietary p-methoxybenzeneselenol, a new organoselenium compound, on azoxymethane(AOM)-induced hepatocarcinogenesis was examined in female F344 rats. Semipurified diets containing 0 and 5 ppm p-methoxybenzeneselenol were fed to the rats, starting at 5 weeks of age until one week after the carcinogen treatment.At 7 weeks of age, all animals except the vehicle-treated controls were given weekly sc injections of AOM (15 mg/kg body weight, 3 times). At 34 weeks after the last AOM treatment, the liver neoplasm incidence and liver tumor multiplicity as well as the incidence of altered liver cell foci were significantly lower in AOM-treated rats fed the diet containing 50 ppm p-methoxybenzeneselenol (tumor incidence 19%, tumor multiplicity 0.45/rat, foci incidence 3.47/cm2) than in AOM-treated animals fed the diet without p-methoxybenzeneselenol (tumor incidence 66%, tumor multiplicity 2.24/rat, foci incidence 12.08/cm2). These results indicate that dietary p-methoxybenzeneselenol at a dose of 50 ppm inhibits AOM-induced hepatic tumorigenesis.

Original languageEnglish (US)
Pages (from-to)462-467
Number of pages6
JournalJapanese Journal of Cancer Research GANN
Volume76
Issue number6
StatePublished - 1985

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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