Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. Furthermore, the micelles inhibit angiogenesis in the chicken ex ovo chorioallantoic membrane assay. The results show that antioxidant micelles containing catechol moieties may be useful in anti-angiogenic therapy to treat various diseases such as cancer. Antioxidant micelles having catechol moieties in the core efficiently inhibit angiogenesis by scavenging reactive oxygen species as shown in the human umbilical vein endothelial cells (HUVECs) tube formation and ex ovo chicken chorioallantoic membrane (CAM) assay. These micelles may be useful in anti-angiogenic therapy to treat various diseases such as cancer.
All Science Journal Classification (ASJC) codes
- Biomedical Engineering
- Pharmaceutical Science