Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice

Takehiko Dohi, Whitney Salz, Marco Costa, Charlotte Ariyan, Giacomo P. Basadonna, Dario C. Altieri

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Survivin is a cancer gene implicated in inhibition of apoptosis and regulation of mitosis, but its function in normal cells has remained elusive. Here, we show that transgenic mice expressing survivin in pancreatic islet β-cells show no changes in cell proliferation, as determined by islet size or islet number. Transplantation of survivin transgenic islets in diabetic recipient mice affords long-term engraftment and stable correction of hyperglycaemia. This involves intrinsic inhibition of β-cell apoptosis, in vivo, and global transcriptional changes in pancreatic islets with upregulation of stress response genes, antagonists of cytokine signalling and promoters of angiogenesis. These broad cytoprotective functions of survivin in vivo might be beneficial for gene therapy of diabetes.

Original languageEnglish (US)
Pages (from-to)438-443
Number of pages6
JournalEMBO Reports
Volume7
Issue number4
DOIs
StatePublished - Apr 1 2006

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Islets of Langerhans Transplantation
Medical problems
Islets of Langerhans
Genes
Apoptosis
Gene therapy
Cell proliferation
Neoplasm Genes
Cytokines
Mitosis
Hyperglycemia
Genetic Therapy
Transgenic Mice
Up-Regulation
Therapeutics
Transplantation
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Dohi, Takehiko ; Salz, Whitney ; Costa, Marco ; Ariyan, Charlotte ; Basadonna, Giacomo P. ; Altieri, Dario C. / Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice. In: EMBO Reports. 2006 ; Vol. 7, No. 4. pp. 438-443.
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Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice. / Dohi, Takehiko; Salz, Whitney; Costa, Marco; Ariyan, Charlotte; Basadonna, Giacomo P.; Altieri, Dario C.

In: EMBO Reports, Vol. 7, No. 4, 01.04.2006, p. 438-443.

Research output: Contribution to journalArticle

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