Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.

Joshua D. Lambert, Jungil Hong, Guang Yu Yang, Jie Liao, Chung S. Yang

Research output: Contribution to journalReview article

373 Citations (Scopus)

Abstract

Many plant polyphenolic compounds have been shown to have cancer-preventing activities in laboratory studies. For example, tea and tea preparations have been shown to inhibit tumorigenesis in a variety of animal models of carcinogenesis, involving organ sites such as the skin, lungs, oral cavity, esophagus, stomach, liver, pancreas, small intestine, colon, and prostate. In some of these models, inhibitory activity was demonstrated when tea was administered during the initiation, promotion, or progression stage of carcinogenesis. The cancer-preventing activities of these and other polyphenols, such as curcumin, genistein, and quercetin, are reviewed. In studies in vitro, many of these compounds have been shown to affect signal transduction pathways, leading to inhibition of cell growth and transformation, enhanced apoptosis, reduced invasive behavior, and slowed angiogenesis. However, the concentrations used in cell culture studies were much higher than those found in vivo. If we propose mechanisms for cancer prevention on the basis of cell line experiments, then these activities must be demonstrated in vivo. The bioavailability, ie, tissue and cellular concentrations, of dietary polyphenols is a determining factor in their cancer-preventing activity in vivo. For example, compounds such as curcumin are effective when applied topically to the skin or administered orally to affect the colon but are not effective in internal organs such as the lungs. More in-depth studies on bioavailability should facilitate correlation of mechanisms determined in vitro with in vivo situations, increase our understanding of dose-response relationships, and facilitate extrapolation of results from animal studies to human situations.

Original languageEnglish (US)
JournalThe American journal of clinical nutrition
Volume81
Issue number1 Suppl
StatePublished - Jan 1 2005

Fingerprint

Polyphenols
Carcinogenesis
Tea
Curcumin
Biological Availability
Neoplasms
Colon
Lung
Skin
Genistein
Quercetin
Esophagus
Small Intestine
Mouth
Prostate
Pancreas
Signal Transduction
Stomach
Animal Models
Cell Culture Techniques

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Lambert, Joshua D. ; Hong, Jungil ; Yang, Guang Yu ; Liao, Jie ; Yang, Chung S. / Inhibition of carcinogenesis by polyphenols : evidence from laboratory investigations. In: The American journal of clinical nutrition. 2005 ; Vol. 81, No. 1 Suppl.
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Inhibition of carcinogenesis by polyphenols : evidence from laboratory investigations. / Lambert, Joshua D.; Hong, Jungil; Yang, Guang Yu; Liao, Jie; Yang, Chung S.

In: The American journal of clinical nutrition, Vol. 81, No. 1 Suppl, 01.01.2005.

Research output: Contribution to journalReview article

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