Inhibition of herpes simplex virus reactivation by dipyridamole

R. B. Tenser, A. Gaydos, K. A. Hay

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Herpes simplex virus (HSV) reactivation from latency was investigated. Reactivation of thymidine kinasenegative HSV, which is defective for reactivation, was greatly enhanced by thymidine (TdR). The reactivationenhancing effect of TdR was blocked by dipyridamole (DPM), a known nucleoside transport inhibitor. DPM also inhibited wild-type HSV reactivation, suggesting potential antiviral use.

Original languageEnglish (US)
Pages (from-to)3657-3659
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number12
Publication statusPublished - Dec 13 2001


All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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