Inhibition of HOS expression and activities by Wnt pathway

Vladimir Spiegelman, Weigang Tang, Masaru Katoh, Thomas J. Slaga, Serge Y. Fuchs

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

βTrCP and HOS are closely related F-box proteins, which play key roles in ubiquitination and degradation of β-catenin and IκB through associating with those phosphorylated substrates and recruiting SCF E3 ubiquitin ligase. Here we report that activation of Wnt/β-catenin signal transduction pathway elevates βTrCP levels but inhibits expression of HOS in 293T cells. Similar disparity is likely to exist in human colorectal tumors. In the NIH3T3 cells, which express HOS, but not βTrCP, Wnt/β-catenin signaling leads to inhibition of HOS promoter activity and NF-κB-driven transcription as well as to stabilization of β-catenin. These results indicate that expression and activities of HOS are negatively regulated by Wnt/β-catenin pathway.

Original languageEnglish (US)
Pages (from-to)856-860
Number of pages5
JournalOncogene
Volume21
Issue number5
DOIs
StatePublished - Jan 24 2002

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Catenins
Wnt Signaling Pathway
SKP Cullin F-Box Protein Ligases
F-Box Proteins
Ubiquitin-Protein Ligases
HEK293 Cells
Ubiquitination
Colorectal Neoplasms
Signal Transduction

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Spiegelman, V., Tang, W., Katoh, M., Slaga, T. J., & Fuchs, S. Y. (2002). Inhibition of HOS expression and activities by Wnt pathway. Oncogene, 21(5), 856-860. https://doi.org/10.1038/sj.onc.1205132
Spiegelman, Vladimir ; Tang, Weigang ; Katoh, Masaru ; Slaga, Thomas J. ; Fuchs, Serge Y. / Inhibition of HOS expression and activities by Wnt pathway. In: Oncogene. 2002 ; Vol. 21, No. 5. pp. 856-860.
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Spiegelman, V, Tang, W, Katoh, M, Slaga, TJ & Fuchs, SY 2002, 'Inhibition of HOS expression and activities by Wnt pathway', Oncogene, vol. 21, no. 5, pp. 856-860. https://doi.org/10.1038/sj.onc.1205132

Inhibition of HOS expression and activities by Wnt pathway. / Spiegelman, Vladimir; Tang, Weigang; Katoh, Masaru; Slaga, Thomas J.; Fuchs, Serge Y.

In: Oncogene, Vol. 21, No. 5, 24.01.2002, p. 856-860.

Research output: Contribution to journalArticle

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