Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids

Richard Grazzini, David Hesk, Ellen Heininger, George Hildenbrandt, C. Channa Reddy, Diana Cox-Foster, June Medford, Richard Craig, Ralph O. Mumma

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

C22:1 ω5-anacardic acid was found to be a good inhibitor of both potato lipoxygenase and ovine prostaglandin endoperoxide synthase with approximate IC50's of 6 and 27 μM, respectively. Very similar inhibition was seen with the crude exudate, rich in ω5-anacardic acids, from glandular trichomes of an arthropod-resistant strain of geranium, Pelargonium xhortorum. The saturated anacardic acid (C22:0 sat), abundant in the trichome exudate of susceptible strains, was nearly as inhibitory toward both prostaglandin endoperoxide synthase and lipoxygenase as the ω5-unsaturated compound. However, the dimethyl derivative of C22:1 ω5-anacardic acid was a poor inhibitor of prostaglandin endoperoxide synthase and caused only moderate (32%) inhibition of lipoxygenase even at 135 μM. The possible role of prostaglandin endoperoxide synthase and lipoxygenase inhibition in the enhanced pest resistance of geraniums which produce the ω5-AnAs is discussed.

Original languageEnglish (US)
Pages (from-to)775-780
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume176
Issue number2
DOIs
StatePublished - Apr 30 1991

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids'. Together they form a unique fingerprint.

  • Cite this

    Grazzini, R., Hesk, D., Heininger, E., Hildenbrandt, G., Reddy, C. C., Cox-Foster, D., Medford, J., Craig, R., & Mumma, R. O. (1991). Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids. Biochemical and Biophysical Research Communications, 176(2), 775-780. https://doi.org/10.1016/S0006-291X(05)80252-9