Inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase disrupts latent inhibition of cued fear conditioning in C57BL/6 mice

Michael C. Lewis, Jennifer A. Davis, Thomas J. Gould

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK) cascade has been implicated in a variety of associative conditioning tasks. However, the role of the MAPK-ERK cascades in modulating conditioning is less clear. The authors examined the effect of the potent and selective MAPK-ERK inhibitor SL327 on latent inhibition of cued fear conditioning. The results demonstrate that 50 mg/kg and 100 mg/kg SL327 disrupt latent inhibition of cued fear conditioning. These data provide evidence for an essential role of the MAPK-ERK cascade in tasks that modulate the strength of associative conditioning. The results are discussed in relation to the molecular mechanisms that support latent inhibition of cued fear conditioning.

Original languageEnglish (US)
Pages (from-to)1444-1449
Number of pages6
JournalBehavioral Neuroscience
Volume118
Issue number6
DOIs
StatePublished - Dec 1 2004

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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