Inhibition of Platelet Adhesion to Collagen by Sulfhydryl Inhibitors

H. Al-Mondhiry, T. H. Spaet

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The studies reported present evidence that a free or intact sulfhydryl group is involved in platelet adhesion to connective tissue. Exposure of platelets to the readily penetrating sulfhydryl inhibitors NEM or PHMB immediately blocks their ability to adhere to connective tissue. PHMBS, which penetrates platelet membrane very slowly, produces an inhibitory effect only after prolonged incubation. These observations suggest that an SH-containing substrate affecting the adhesion reaction is probably located beneath the plasma membrane of the platelet.

Original languageEnglish (US)
Pages (from-to)878-882
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume135
Issue number3
DOIs
StatePublished - Dec 1970

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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