Inhibition of soybean and potato lipoxygenases by Bhilawanols from Bhilawan (Semecarpus anacardium) nut shell liquid and some synthetic salicylic acid analogues

Kyatanahalli S. Nagabhushana, S. Umamaheshwari, Felismino E. Tocoli, Sandeep K. Prabhu, Ivan R. Green, Candadai S. Ramadoss

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Bhilawanol diene (3) isolated from bhilawan nut shell liquid was found to be a potent inhibitor of both soybean and potato lipoxygenases with IC50 values of 0.85 μM and 1.1 μM, respectively. However, the monoene (2) and saturated (1) bhilawanols exhibited relatively lower inhibitory activity. In addition, inhibition studies with synthetic analogues of salicylic acid (4-8) suggested that the unsaturated lipophilic side chain may be an absolute requirement for inhibitory activity.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume17
Issue number4
DOIs
StatePublished - Aug 1 2002

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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