Bhilawanol diene (3) isolated from bhilawan nut shell liquid was found to be a potent inhibitor of both soybean and potato lipoxygenases with IC50 values of 0.85 μM and 1.1 μM, respectively. However, the monoene (2) and saturated (1) bhilawanols exhibited relatively lower inhibitory activity. In addition, inhibition studies with synthetic analogues of salicylic acid (4-8) suggested that the unsaturated lipophilic side chain may be an absolute requirement for inhibitory activity.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Enzyme Inhibition and Medicinal Chemistry|
|State||Published - Aug 1 2002|
All Science Journal Classification (ASJC) codes
- Drug Discovery