Inhibition of the alkylation of nucleic acids and of the metabolism of 1,2-dimethylhydrazine by aminoacetonitrile

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Abstract

Pretreatment of rats with aminoacetonitrile inhibited the metabolism of [14C]1,2-dimethylhydrazine to 14CO2 and increased the expiration of [14C]-azomethane. Alkylation of nucleic acids following administration of 1,2-dimethylhydrazine was reduced by aminoacetonitrile to 5% of control levels in liver, 11% of control levels in kidney and 43% of control levels in colon.

Original languageEnglish (US)
Pages (from-to)273-279
Number of pages7
JournalChemico-Biological Interactions
Volume23
Issue number2
DOIs
StatePublished - Nov 1978

All Science Journal Classification (ASJC) codes

  • Toxicology

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