Inhibition of vascular endothelial growth factor expression and production by triptolide

Kebin Hu, Zhi Hong Liu, Dong Liu, Lei Shi Li

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Triptolide, the major component of the diterpenoids of the Chinese herb Tripterygium wilfordii Hook f. (Celastraceae), inhibited vascular endothelial growth factor expression and secretion in endothelial cells treated by 12-O-tetradecanoylphorbol 13-acetate dose-dependently. This effect may be one of the mechanisms underlying the therapeutic effects of triptolide on rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)368-369
Number of pages2
JournalPlanta Medica
Volume68
Issue number4
DOIs
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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