Inhibition of vascular endothelial growth factor expression and production by triptolide

Kebin Hu, Zhi Hong Liu, Dong Liu, Lei Shi Li

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Triptolide, the major component of the diterpenoids of the Chinese herb Tripterygium wilfordii Hook f. (Celastraceae), inhibited vascular endothelial growth factor expression and secretion in endothelial cells treated by 12-O-tetradecanoylphorbol 13-acetate dose-dependently. This effect may be one of the mechanisms underlying the therapeutic effects of triptolide on rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)368-369
Number of pages2
JournalPlanta Medica
Volume68
Issue number4
DOIs
StatePublished - May 20 2002

Fingerprint

Vascular Endothelial Growth Factor A
Celastraceae
Tripterygium
Hooks
Diterpenes
Endothelial cells
Therapeutic Uses
Tetradecanoylphorbol Acetate
Rheumatoid Arthritis
Acetates
Endothelial Cells
triptolide

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Hu, Kebin ; Liu, Zhi Hong ; Liu, Dong ; Li, Lei Shi. / Inhibition of vascular endothelial growth factor expression and production by triptolide. In: Planta Medica. 2002 ; Vol. 68, No. 4. pp. 368-369.
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Inhibition of vascular endothelial growth factor expression and production by triptolide. / Hu, Kebin; Liu, Zhi Hong; Liu, Dong; Li, Lei Shi.

In: Planta Medica, Vol. 68, No. 4, 20.05.2002, p. 368-369.

Research output: Contribution to journalArticle

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