Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds

Harshani R. Lawrence, Roberta Pireddu, Liwei Chen, Yunting Luo, Shen-shu Sung, Ann Marie Szymanski, M. L.Richard Yip, Wayne C. Guida, Saïd M. Sebti, Jie Wu, Nicholas J. Lawrence

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56 Scopus citations

Abstract

Screening of the NCI diversity set of compounds has led to the identification of 5 (NSC-117199), which inhibits the protein tyrosine phosphatase (PTP) Shp2 with an IC50 of 47 μM. A focused library incorporating an isatin scaffold was designed and evaluated for inhibition of Shp2 and Shp1 PTP activities. Several compounds were identified that selectively inhibit Shp2 over Shp1 and PTP1B with low to submicromolar activity. A model for the binding of the active compounds is proposed.

Original languageEnglish (US)
Pages (from-to)4948-4956
Number of pages9
JournalJournal of Medicinal Chemistry
Volume51
Issue number16
DOIs
StatePublished - Aug 28 2008

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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    Lawrence, H. R., Pireddu, R., Chen, L., Luo, Y., Sung, S., Szymanski, A. M., Yip, M. L. R., Guida, W. C., Sebti, S. M., Wu, J., & Lawrence, N. J. (2008). Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. Journal of Medicinal Chemistry, 51(16), 4948-4956. https://doi.org/10.1021/jm8002526