Initial respiratory status in hyperleukocytic acute myeloid leukemia: Prognostic significance and effect of leukapheresis

Andry Van De Louw, Coursen W. Schneider, Ruchi J. Desai, David Claxton

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

This study investigated whether initial respiratory status in hyperleukocytic acute myeloid leukemia (AML), as defined by oxygen/ventilatory support, is (1) associated with early mortality and overall survival and (2) improved after leukapheresis. A retrospective chart review of 89 patients requiring leukapheresis was performed. White blood cell count (WBC) decreased from 153 (56-475) × 109/L to 60 (17-259) × 109/L after first leukapheresis (p < 0.01). Initial respiratory status was room air (n = 40), low (n = 31) or high flow oxygen therapy (n = 8) or mechanical ventilation (n = 10). As compared to admission, respiratory status significantly deteriorated after both first and second leukapheresis (p < 0.01) and was not different at day 5 for patients still alive (p = 0.131). Both day 28 mortality and overall survival were significantly affected by initial respiratory status (p < 0.01). Despite being effective in reducing WBC, leukapheresis did not improve respiratory status of hyperleukocytic AML patients, a factor strongly associated with survival.

Original languageEnglish (US)
Pages (from-to)1319-1326
Number of pages8
JournalLeukemia and Lymphoma
Volume57
Issue number6
DOIs
StatePublished - Jun 2 2016

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Initial respiratory status in hyperleukocytic acute myeloid leukemia: Prognostic significance and effect of leukapheresis'. Together they form a unique fingerprint.

Cite this