Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure

Mohammadreza Mehdizadeh, Hong Weng, Dipendra Gyawali, Liping Tang, Jian Yang

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

The existing surgical adhesives are not ideal for wet tissue adhesion required in many surgeries such as those for internal organs. Developing surgical adhesives with strong wet tissue adhesion, controlled degradability and mechanical properties, and excellent biocompatibility has been a significant challenge. Herein, learning from nature, we report a one-step synthesis of a family of injectable citrate-based mussel-inspired bioadhesives (iCMBAs) for surgical use. Within the formulations investigated, iCMBAs showed 2.5-8.0 folds stronger wet tissue adhesion strength over the clinically used fibrin glue, demonstrated controlled degradability and tissue-like elastomeric mechanical properties, and exhibited excellent cyto/tissue-compatibility both in vitro and in vivo. iCMBAs were able to stop bleeding instantly and suturelessly, and close wounds (2 cm long × 0.5 cm deep) created on the back of Sprague-Dawley rats, which is impossible when using existing gold standard, fibrin glue, due to its weak wet tissue adhesion strength. Equally important, the new bioadhesives facilitate wound healing, and are completely degraded and absorbed without eliciting significant inflammatory response. Our results support that iCMBA technology is highly translational and could have broad impact on surgeries where surgical tissue adhesives, sealants, and hemostatic agents are used.

Original languageEnglish (US)
Pages (from-to)7972-7983
Number of pages12
JournalBiomaterials
Volume33
Issue number32
DOIs
StatePublished - Nov 1 2012

Fingerprint

Tissue Adhesions
Bivalvia
Citric Acid
Tissue
Fibrin Tissue Adhesive
Injections
Wounds and Injuries
Adhesives
Bond strength (materials)
Tissue Adhesives
Glues
Surgery
Histocompatibility
Hemostatics
Adhesion
Wound Healing
Sprague Dawley Rats
Mechanical properties
Sealants
Learning

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Mehdizadeh, Mohammadreza ; Weng, Hong ; Gyawali, Dipendra ; Tang, Liping ; Yang, Jian. / Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure. In: Biomaterials. 2012 ; Vol. 33, No. 32. pp. 7972-7983.
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Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure. / Mehdizadeh, Mohammadreza; Weng, Hong; Gyawali, Dipendra; Tang, Liping; Yang, Jian.

In: Biomaterials, Vol. 33, No. 32, 01.11.2012, p. 7972-7983.

Research output: Contribution to journalArticle

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