Injection of a minuscule dose of FeCl3 within the ventrolateral striatum causes a chronic disturbance of the integrative function within the limbic part of the ventral striatum

W. Kolasiewicz, T. Jaros, C. Heim, M. Melzacka, M. Sieklucka, N. Weiner, W. Wesemann, P. Riederer, K. H. Sontag

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The present study shows that low amounts of applied iron have a potent effect on the ventrolateral striatum. This is reflected by an influence on spontaneous night activity, cognitive behaviour during the water maze navigation task, exploratory activity and in response to postsynaptic apomorphine stimulation. Such functional disturbances could be observed up to months after a single application of either 0.3 μg or 1.5 μg FeCl3. The low dose of iron stimulates while 1.5 μg inhibits the spontaneous dopaminedependent locomotor night and explorative activity. The low concentration of ionic iron injected intrastriatally also increases lipid peroxidation in striatal and hippocampal tissues. These results suggest that the functional integrity of the ventral striatum and the regulation of the iron metabolism are critical for the sensorimotor performance.

Original languageEnglish (US)
Pages (from-to)15-29
Number of pages15
JournalJournal of Neural Transmission - Parkinson's Disease and Dementia Section
Volume9
Issue number1
DOIs
StatePublished - Feb 1 1995

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Iron
Injections
Corpus Striatum
Apomorphine
Lipid Peroxidation
Ventral Striatum
Water

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology

Cite this

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title = "Injection of a minuscule dose of FeCl3 within the ventrolateral striatum causes a chronic disturbance of the integrative function within the limbic part of the ventral striatum",
abstract = "The present study shows that low amounts of applied iron have a potent effect on the ventrolateral striatum. This is reflected by an influence on spontaneous night activity, cognitive behaviour during the water maze navigation task, exploratory activity and in response to postsynaptic apomorphine stimulation. Such functional disturbances could be observed up to months after a single application of either 0.3 μg or 1.5 μg FeCl3. The low dose of iron stimulates while 1.5 μg inhibits the spontaneous dopaminedependent locomotor night and explorative activity. The low concentration of ionic iron injected intrastriatally also increases lipid peroxidation in striatal and hippocampal tissues. These results suggest that the functional integrity of the ventral striatum and the regulation of the iron metabolism are critical for the sensorimotor performance.",
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Injection of a minuscule dose of FeCl3 within the ventrolateral striatum causes a chronic disturbance of the integrative function within the limbic part of the ventral striatum. / Kolasiewicz, W.; Jaros, T.; Heim, C.; Melzacka, M.; Sieklucka, M.; Weiner, N.; Wesemann, W.; Riederer, P.; Sontag, K. H.

In: Journal of Neural Transmission - Parkinson's Disease and Dementia Section, Vol. 9, No. 1, 01.02.1995, p. 15-29.

Research output: Contribution to journalArticle

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AU - Kolasiewicz, W.

AU - Jaros, T.

AU - Heim, C.

AU - Melzacka, M.

AU - Sieklucka, M.

AU - Weiner, N.

AU - Wesemann, W.

AU - Riederer, P.

AU - Sontag, K. H.

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