The present study shows that low amounts of applied iron have a potent effect on the ventrolateral striatum. This is reflected by an influence on spontaneous night activity, cognitive behaviour during the water maze navigation task, exploratory activity and in response to postsynaptic apomorphine stimulation. Such functional disturbances could be observed up to months after a single application of either 0.3 μg or 1.5 μg FeCl3. The low dose of iron stimulates while 1.5 μg inhibits the spontaneous dopaminedependent locomotor night and explorative activity. The low concentration of ionic iron injected intrastriatally also increases lipid peroxidation in striatal and hippocampal tissues. These results suggest that the functional integrity of the ventral striatum and the regulation of the iron metabolism are critical for the sensorimotor performance.
|Original language||English (US)|
|Number of pages||15|
|Journal||Journal of Neural Transmission - Parkinson's Disease and Dementia Section|
|State||Published - Feb 1 1995|
All Science Journal Classification (ASJC) codes
- Clinical Neurology