Injury mechanisms in acute intracerebral hemorrhage

D. Andrew Wilkinson, Aditya S. Pandey, B. Gregory Thompson, Richard F. Keep, Ya Hua, Guohua Xi

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

Intracerebral hemorrhage (ICH) is the most common hemorrhagic stroke subtype, and rates are increasing with an aging population. Despite an increase in research and trials of therapies for ICH, mortality remains high and no interventional therapy has been demonstrated to improve outcomes. We review known mechanisms of injury, recent clinical trial results, and newly discovered signaling pathways involved in hematoma clearance. Enthusiasm remains high for methods of minimally invasive clot removal as well as pharmacologic strategies to improve recovery after ICH, both of which are currently being evaluated in clinical trials. This article is part of the Special Issue entitled ‘Cerebral Ischemia’.

Original languageEnglish (US)
Pages (from-to)240-248
Number of pages9
JournalNeuropharmacology
Volume134
DOIs
StatePublished - May 15 2018

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cellular and Molecular Neuroscience

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