Innate Lymphoid Cells: A Promising New Regulator in Fibrotic Diseases

Yi Zhang, Jun Tang, Zhiqiang Tian, Jennifer C. van Velkinburgh, Jianxun Song, Yuzhang Wu, Bing Ni

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Fibrosis is a consequence of chronic inflammation and the persistent accumulation of extracellular matrix, for which the cycle of tissue injury and repair becomes a predominant feature. Both the innate and adaptive immune systems play key roles in the progress of fibrosis. The recently identified subsets of innate lymphoid cells (ILCs), which are mainly localize to epithelial surfaces, have been characterized as regulators of chronic inflammation and tissue remodeling, representing a functional bridge between the innate and adaptive immunity. Moreover, recent research has implicated ILCs as potential contributing factors to several kinds of fibrosis diseases, such as hepatic fibrosis and pulmonary fibrosis. Here, we will summarize and discuss the key roles of ILCs and their related factors in fibrotic diseases and their potential for translation to the clinic.

Original languageEnglish (US)
Pages (from-to)399-414
Number of pages16
JournalInternational Reviews of Immunology
Volume35
Issue number5
DOIs
StatePublished - Sep 2 2016

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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