TY - JOUR
T1 - Innate lymphoid cells (ILC) in SARS-CoV-2 infection
AU - Kumar, Amrita
AU - Cao, Weiping
AU - Endrias, Kedan
AU - Kuchipudi, Suresh V.
AU - Mittal, Suresh K.
AU - Sambhara, Suryaprakash
N1 - Funding Information:
This work was partly supported by Public Health Service grant AI158177 from the National Institute of Allergy and Infectious Diseases .
Publisher Copyright:
© 2021
PY - 2021/8
Y1 - 2021/8
N2 - Innate Lymphoid Cells (ILCs) are a class of innate immune cells that form the first line of defense against internal or external abiotic and biotic challenges in the mammalian hosts. As they reside in both the lymphoid and non-lymphoid tissues, they are involved in clearing the pathogens through direct killing or by secretion of cytokines that modulate the adaptive immune responses. There is burgeoning evidence that these cells are important in clearing viral infections; therefore, it is critical to understand their role in the resolution or exacerbation of the disease caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2). In this review, we summarize the recent findings related to ILCs in response to SARS-CoV-2 infections.
AB - Innate Lymphoid Cells (ILCs) are a class of innate immune cells that form the first line of defense against internal or external abiotic and biotic challenges in the mammalian hosts. As they reside in both the lymphoid and non-lymphoid tissues, they are involved in clearing the pathogens through direct killing or by secretion of cytokines that modulate the adaptive immune responses. There is burgeoning evidence that these cells are important in clearing viral infections; therefore, it is critical to understand their role in the resolution or exacerbation of the disease caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2). In this review, we summarize the recent findings related to ILCs in response to SARS-CoV-2 infections.
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U2 - 10.1016/j.mam.2021.101008
DO - 10.1016/j.mam.2021.101008
M3 - Article
C2 - 34399986
AN - SCOPUS:85112556181
VL - 80
JO - Molecular Aspects of Medicine
JF - Molecular Aspects of Medicine
SN - 0098-2997
M1 - 101008
ER -