Renal cell carcinoma is a serious medical problem in the United States, with nearly 35,000 new cases and >12,000 cancer-related deaths reported in 2003 (21). A number exciting advances in understanding the genetics, biology, and prognostic and predictive factors for renal cell carcinoma, as well as better local therapies, are improving the outlook for patients with advanced renal cell carcinoma. Although combinations of various treatment approaches might produce synergistic antitumor activity, we lack the mechanisms to rapidly and efficiently identify potentially effective combinations. Good surrogates of biological effect are needed to efficiently study strategies for combining various approaches. Nonetheless, for the first time in many years, investigators are primed to make significant advances in the treatment of renal cell carcinoma.
All Science Journal Classification (ASJC) codes
- Cancer Research