TY - JOUR
T1 - Insights into the role of zinc(II) sites in hydrolytic enzymes
T2 - Study of the ZnII/X/(py)2CO (X = Cl-, N3-, SO42-; (py)2CO=di-2-pyridyl ketone) reaction systems
AU - Nishioka, Kenichi
AU - Rice, Judd C.
AU - Sarma, Kavitha
AU - Erdjument-Bromage, Hediye
AU - Werner, Janis
AU - Wang, Yanming
AU - Chuikov, Sergei
AU - Valenzuela, Pablo
AU - Tempst, Paul
AU - Steward, Ruth
AU - Lis, John T.
AU - Allis, C. David
AU - Reinberg, Danny
PY - 2002/9/1
Y1 - 2002/9/1
N2 - A bioinorganic model approach for the investigation of substrate activation by zinc active sites in hydrolytic enzymes has been initiated. Several reaction schemes involving the substrate analogue di-2-pyridyl ketone, (py)2CO, and Zn(II) sources afforded the new complexes [ZnCl2{(py)2CO}](1), [ZnCl2{(py)2C(OMe)(OH)}](2), [Zn2Cl2{(py)2C(OMe)O}2](3), [Zn2(N3)2{(py)2C(OMe) O}2](4) and [Zn2(SO4)2{(py)2C(OMe) (OH)}2(MeOH)2](5), which have been characterized by single-crystal X-ray crystallography and spectroscopic techniques. The chemical and structural identity of the products depends on the solvent, the hydroxide concentration and the nature of the inorganic anion. The biological relevance of the prepared complexes is also discussed.
AB - A bioinorganic model approach for the investigation of substrate activation by zinc active sites in hydrolytic enzymes has been initiated. Several reaction schemes involving the substrate analogue di-2-pyridyl ketone, (py)2CO, and Zn(II) sources afforded the new complexes [ZnCl2{(py)2CO}](1), [ZnCl2{(py)2C(OMe)(OH)}](2), [Zn2Cl2{(py)2C(OMe)O}2](3), [Zn2(N3)2{(py)2C(OMe) O}2](4) and [Zn2(SO4)2{(py)2C(OMe) (OH)}2(MeOH)2](5), which have been characterized by single-crystal X-ray crystallography and spectroscopic techniques. The chemical and structural identity of the products depends on the solvent, the hydroxide concentration and the nature of the inorganic anion. The biological relevance of the prepared complexes is also discussed.
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U2 - 10.1016/S1387-7003(02)00542-7
DO - 10.1016/S1387-7003(02)00542-7
M3 - Article
AN - SCOPUS:0036724612
VL - 5
SP - 719
EP - 723
JO - Inorganic Chemistry Communication
JF - Inorganic Chemistry Communication
SN - 1387-7003
IS - 9
ER -