Insulin-like growth factor 1 and growth hormone binding protein in depression: A preliminary communication

Bettina Franz, Daniel J. Buysse, Christine R. Cherry, Nicola S. Gray, Victoria J. Grochocinski, Ellen Frank, David J. Kupfer

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26 Scopus citations

Abstract

This study was undertaken in order to advance our understanding of the distal growth hormone axis in depression. Insulin-like growth factor 1 (IGF-1) and growth hormone binding protein (GHBP) were measured in a group of 19 depressed women and a group of 16 healthy women. Using a generalized linear model, IGF-1 levels were negatively correlated with age (p = 0.0001), influenced by menstrual phase (p = 0.016), and significantly increased in the depressed group (p = 0.02). Using the same type of analysis, GHBP was significantly related to menstrual phase (p = 0.0001) and body mass index (p = 0.0001), but was not significantly different in patients and controls. IGF-1 and GHBP were positively correlated among healthy subjects (r = 0.46, p = 0.08), but not among depressed patients (r = -0.16, p = 0.51), although these correlation coefficients were not statistically significantly different from each other. These findings confirm the importance of several physiological factors in the regulation of IGF-1 and GHBP, and suggest that depression further influences this regulation.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalJournal of Psychiatric Research
Volume33
Issue number2
DOIs
StatePublished - Mar 1 1999

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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