Insulin-like growth factor system in patients with HIV infection: Effect of exogenous growth hormone administration

Dennis C. Mynarcik, Robert A. Frost, Charles H. Lang, Kim DeCristofaro, Margaret A. McNurlan, Peter J. Garlick, Roy T. Steigbigel, Jack Fuhrer, Sang Ahnn, Marie C. Gelato

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The purpose of this study was to characterize changes in the levels of insulin-like growth factor-I (IGF-I) and IGF binding proteins (BP) 1, 2, and 3 in HIV-infected adults throughout the course of their disease, and to assess the responsiveness of the IGF system components to growth hormone (GH) administration (6 mg/day) for 2 weeks. Healthy control study subjects (n = 10) were compared with patients who were either HIV-positive (n = 9), had AIDS without weight loss (n = 13), or had AIDS with >10% weight loss (n = 6), all of whom had been free of acute illness for at least 3 months. Under basal conditions, fasting serum concentrations of epinephrine, norepinephrine, cortisol, glucagon, insulin, IGF-I, and IGFBP-3 were not significantly different among the four groups. The serum concentrations of IGFBP-1 and IGFBP-2 were significantly higher in AIDS patients with wasting than in the other three groups (p < .05). In addition, there was a statistically significant positive correlation between the levels of IGFBP-1 (p = .004) and IGFBP-2 (p = .03) and the stage of disease. Following GH administration, the serum concentrations of insulin and IGF-I were increased in all groups (p < .05). In addition, the increases in insulin levels correlated with stage of disease (p = .004). The responses of the IGFBPs were more variable. GH administration significantly increased the levels of IGFBP-3 in all groups except the patients with AIDS wasting, whereas the levels of IGFBP-1 were significantly decreased in controls and AIDS patients. These results demonstrate that there is a continuum of both elevations in the IGFBPs and altered metabolic responsiveness in patients infected with HIV that increases with the severity of the disease. These data also demonstrate that AIDS patients, who are free from secondary infection, respond to administration of GH by significantly increasing hepatic IGF-I production.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume22
Issue number1
DOIs
StatePublished - Sep 1 1999

Fingerprint

Insulin-Like Growth Factor Binding Protein 1
Somatomedins
Growth Hormone
HIV Infections
Acquired Immunodeficiency Syndrome
Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor I
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor Binding Proteins
HIV
Insulin
Weight Loss
Serum
Glucagon
Coinfection
Epinephrine
Hydrocortisone
Fasting
Norepinephrine
Liver

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Virology

Cite this

Mynarcik, Dennis C. ; Frost, Robert A. ; Lang, Charles H. ; DeCristofaro, Kim ; McNurlan, Margaret A. ; Garlick, Peter J. ; Steigbigel, Roy T. ; Fuhrer, Jack ; Ahnn, Sang ; Gelato, Marie C. / Insulin-like growth factor system in patients with HIV infection : Effect of exogenous growth hormone administration. In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1999 ; Vol. 22, No. 1. pp. 49-55.
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Insulin-like growth factor system in patients with HIV infection : Effect of exogenous growth hormone administration. / Mynarcik, Dennis C.; Frost, Robert A.; Lang, Charles H.; DeCristofaro, Kim; McNurlan, Margaret A.; Garlick, Peter J.; Steigbigel, Roy T.; Fuhrer, Jack; Ahnn, Sang; Gelato, Marie C.

In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol. 22, No. 1, 01.09.1999, p. 49-55.

Research output: Contribution to journalArticle

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T1 - Insulin-like growth factor system in patients with HIV infection

T2 - Effect of exogenous growth hormone administration

AU - Mynarcik, Dennis C.

AU - Frost, Robert A.

AU - Lang, Charles H.

AU - DeCristofaro, Kim

AU - McNurlan, Margaret A.

AU - Garlick, Peter J.

AU - Steigbigel, Roy T.

AU - Fuhrer, Jack

AU - Ahnn, Sang

AU - Gelato, Marie C.

PY - 1999/9/1

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N2 - The purpose of this study was to characterize changes in the levels of insulin-like growth factor-I (IGF-I) and IGF binding proteins (BP) 1, 2, and 3 in HIV-infected adults throughout the course of their disease, and to assess the responsiveness of the IGF system components to growth hormone (GH) administration (6 mg/day) for 2 weeks. Healthy control study subjects (n = 10) were compared with patients who were either HIV-positive (n = 9), had AIDS without weight loss (n = 13), or had AIDS with >10% weight loss (n = 6), all of whom had been free of acute illness for at least 3 months. Under basal conditions, fasting serum concentrations of epinephrine, norepinephrine, cortisol, glucagon, insulin, IGF-I, and IGFBP-3 were not significantly different among the four groups. The serum concentrations of IGFBP-1 and IGFBP-2 were significantly higher in AIDS patients with wasting than in the other three groups (p < .05). In addition, there was a statistically significant positive correlation between the levels of IGFBP-1 (p = .004) and IGFBP-2 (p = .03) and the stage of disease. Following GH administration, the serum concentrations of insulin and IGF-I were increased in all groups (p < .05). In addition, the increases in insulin levels correlated with stage of disease (p = .004). The responses of the IGFBPs were more variable. GH administration significantly increased the levels of IGFBP-3 in all groups except the patients with AIDS wasting, whereas the levels of IGFBP-1 were significantly decreased in controls and AIDS patients. These results demonstrate that there is a continuum of both elevations in the IGFBPs and altered metabolic responsiveness in patients infected with HIV that increases with the severity of the disease. These data also demonstrate that AIDS patients, who are free from secondary infection, respond to administration of GH by significantly increasing hepatic IGF-I production.

AB - The purpose of this study was to characterize changes in the levels of insulin-like growth factor-I (IGF-I) and IGF binding proteins (BP) 1, 2, and 3 in HIV-infected adults throughout the course of their disease, and to assess the responsiveness of the IGF system components to growth hormone (GH) administration (6 mg/day) for 2 weeks. Healthy control study subjects (n = 10) were compared with patients who were either HIV-positive (n = 9), had AIDS without weight loss (n = 13), or had AIDS with >10% weight loss (n = 6), all of whom had been free of acute illness for at least 3 months. Under basal conditions, fasting serum concentrations of epinephrine, norepinephrine, cortisol, glucagon, insulin, IGF-I, and IGFBP-3 were not significantly different among the four groups. The serum concentrations of IGFBP-1 and IGFBP-2 were significantly higher in AIDS patients with wasting than in the other three groups (p < .05). In addition, there was a statistically significant positive correlation between the levels of IGFBP-1 (p = .004) and IGFBP-2 (p = .03) and the stage of disease. Following GH administration, the serum concentrations of insulin and IGF-I were increased in all groups (p < .05). In addition, the increases in insulin levels correlated with stage of disease (p = .004). The responses of the IGFBPs were more variable. GH administration significantly increased the levels of IGFBP-3 in all groups except the patients with AIDS wasting, whereas the levels of IGFBP-1 were significantly decreased in controls and AIDS patients. These results demonstrate that there is a continuum of both elevations in the IGFBPs and altered metabolic responsiveness in patients infected with HIV that increases with the severity of the disease. These data also demonstrate that AIDS patients, who are free from secondary infection, respond to administration of GH by significantly increasing hepatic IGF-I production.

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