Insulin receptor phosphorylation may not be a prerequisite for acute insulin action

Ian A. Simpson, José A. Hedo

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

An antiserum to the insulin receptor mimicked insulin's acute actions on glucose transport, phosphorylation of integral membrane proteins, and internalization of the insulin receptor in isolated rat adipose cells. These insulinomimetic actions of the antiserum occurred without the equivalent increase in phosphorylation of the β subunit of the insulin receptor observed with insulin. Thus, a role of receptor phosphorylation in acute insulin action is now questioned.

Original languageEnglish (US)
Pages (from-to)1301-1304
Number of pages4
JournalScience
Volume223
Issue number4642
DOIs
StatePublished - Jan 1 1984

All Science Journal Classification (ASJC) codes

  • General

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