Insulin resistance is associated with depression risk in polycystic ovary syndrome

Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To test the hypothesis that insulin resistance is associated with depression risk in polycystic ovary syndrome (PCOS). Design: Secondary analysis of data from a multicenter randomized trial. Setting: Multicenter university-based clinical practices. Patient(s): Seven hundred thirty-eight women with PCOS by modified Rotterdam criteria seeking pregnancy enrolled in a randomized clinical trial comparing clomiphene citrate versus letrozole. Intervention(s): The Primary Care Evaluation of Mental Disorders Patient Health Questionnaire was self-administered to identify depression using a validated algorithm at enrollment. Demographic and anthropometric data were collected, and serum assays were performed. Insulin resistance was estimated using the homeostatic model of insulin resistance (HOMA-IR), with a cutoff of >2.2 considered abnormal. Main Outcome Measure(s): Demographic, endocrine, and metabolic parameters associated with depression. Result(s): In a univariate logistic regression analysis, elevated HOMA-IR was associated with 2.3-fold increased odds of depression (odds ratio [OR] = 2.32; 95% confidence interval [CI], 1.28–4.21). This association remained significant after controlling for age and body mass index (adjusted OR [aOR] = 2.23; 95% CI, 1.11–4.46) and in a model including additional potential confounders (aOR = 2.03; 95% CI, 1.00–4.16). Conclusion(s): Insulin resistance has a strong and independent association with depression in PCOS and may serve as a physiologic mediator. Our findings corroborate a growing body of evidence linking insulin resistance to depressed mood. The association between insulin resistance and depressed mood warrants further investigation to elucidate mechanisms and identify potential therapeutic targets.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalFertility and sterility
Volume110
Issue number1
DOIs
StatePublished - Jul 1 2018

Fingerprint

Polycystic Ovary Syndrome
Insulin Resistance
Depression
letrozole
Confidence Intervals
Odds Ratio
Demography
Clomiphene
Mentally Ill Persons
Mental Disorders
Multicenter Studies
Primary Health Care
Body Mass Index
Randomized Controlled Trials
Logistic Models
Regression Analysis
Outcome Assessment (Health Care)
Pregnancy
Health
Serum

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network (2018). Insulin resistance is associated with depression risk in polycystic ovary syndrome. Fertility and sterility, 110(1), 27-34. https://doi.org/10.1016/j.fertnstert.2018.03.009
Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network. / Insulin resistance is associated with depression risk in polycystic ovary syndrome. In: Fertility and sterility. 2018 ; Vol. 110, No. 1. pp. 27-34.
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Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network 2018, 'Insulin resistance is associated with depression risk in polycystic ovary syndrome', Fertility and sterility, vol. 110, no. 1, pp. 27-34. https://doi.org/10.1016/j.fertnstert.2018.03.009

Insulin resistance is associated with depression risk in polycystic ovary syndrome. / Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network.

In: Fertility and sterility, Vol. 110, No. 1, 01.07.2018, p. 27-34.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Insulin resistance is associated with depression risk in polycystic ovary syndrome

AU - Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network

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AU - Legro, Richard

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AU - Huddleston, Heather G.

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Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network. Insulin resistance is associated with depression risk in polycystic ovary syndrome. Fertility and sterility. 2018 Jul 1;110(1):27-34. https://doi.org/10.1016/j.fertnstert.2018.03.009