Integrated System Health Management (ISHM) technologies have been developed to address safety, replace time-based maintenance with condition based maintenance, and to reduce life cycle costs. Traditional space system designs have focused on safety to minimize the risk to crew and to protect the public, astronauts and pilots, the NASA workforce, and high-value equipment and property. Systems have relied on high reliability components to provide the necessary safety margins and avoid operational mission failures. The current vision for future manned and unmanned space missions to the International Space Station, the Moon, Mars, and beyond, will require longer duration missions and will rely on complex assemblages of components. Increased mission duration and complexity increase the probability of operational mission failures that must be mitigated without jeopardizing safety or the objectives of the current or future missions that might reuse critical mission components. ISHM technology will be essential for providing near-real-time assessments of system capability, safety margins, and maintenance and sustainment requirements. The Applied Research Lab has conducted a series of workshops for NASA which focused on defining requirements for Integrated System Health Monitoring and for the integration of health monitoring and control to provide Intelligent Self Situational Awareness (ISSA). The results of these workshops indicate that the benefits of ISHM and greater integration between ISHM and control include increased safety and mission assurance, the ability to rapidly respond to system failures, and decreased operator workload. Emerging open system standards such as OSA-EAI provide a framework for integrating system health monitoring with control functionality in spacecraft avionics systems. The purpose of this paper is to describe areas where system health monitoring can impact safety, reliability and sustainment in space applications and present the results of workshops conducted for NASA to identify requirements for the integration of health monitoring and control in future space systems.