Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia

Todd L. Edwards, Xu Wang, Qi Chen, Brandon Wormly, Brien Riley, F. Anthony O'Neill, Dermot Walsh, Marylyn Deriggi Ritchie, Kenneth S. Kendler, Xiangning Chen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Schizophrenia is a common psychotic mental disorder that is believed to result from the effects of multiple genetic and environmental factors. In this study, we explored gene-gene interactions and main effects in both case-control (657 cases and 411 controls) and family-based (273 families, 1350 subjects) datasets of English or Irish ancestry. Fifty three markers in 8 genes were genotyped in the family sample and 44 markers in 7 genes were genotyped in the case-control sample. The Multifactor Dimensionality Reduction Pedigree Disequilibrium Test (MDR-PDT) was used to examine epistasis in the family dataset and a 3-locus model was identified (permuted p = 0.003). The 3-locus model involved the IL3 (rs2069803), RGS4 (rs2661319), and DTNBP1 (rs2619539) genes. We used MDR to analyze the case-control dataset containing the same markers typed in the RGS4, IL3 and DTNBP1 genes and found evidence of a joint effect between IL3 (rs31400) and DTNBP1 (rs760761) (cross-validation consistency 4/5, balanced prediction accuracy = 56.84%, p = 0.019). While this is not a direct replication, the results obtained from both the family and case-control samples collectively suggest that IL3 and DTNBP1 are likely to interact and jointly contribute to increase risk for schizophrenia. We also observed a significant main effect in DTNBP1, which survived correction for multiple comparisons, and numerous nominally significant effects in several genes.

Original languageEnglish (US)
Pages (from-to)208-217
Number of pages10
JournalSchizophrenia Research
Volume106
Issue number2-3
DOIs
StatePublished - Dec 1 2008

Fingerprint

Interleukin-3
Schizophrenia
Carrier Proteins
Genes
Multifactor Dimensionality Reduction
Pedigree
dystrobrevin
Mental Disorders
Psychotic Disorders
Datasets

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Edwards, T. L., Wang, X., Chen, Q., Wormly, B., Riley, B., O'Neill, F. A., ... Chen, X. (2008). Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. Schizophrenia Research, 106(2-3), 208-217. https://doi.org/10.1016/j.schres.2008.07.022
Edwards, Todd L. ; Wang, Xu ; Chen, Qi ; Wormly, Brandon ; Riley, Brien ; O'Neill, F. Anthony ; Walsh, Dermot ; Ritchie, Marylyn Deriggi ; Kendler, Kenneth S. ; Chen, Xiangning. / Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. In: Schizophrenia Research. 2008 ; Vol. 106, No. 2-3. pp. 208-217.
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Edwards, TL, Wang, X, Chen, Q, Wormly, B, Riley, B, O'Neill, FA, Walsh, D, Ritchie, MD, Kendler, KS & Chen, X 2008, 'Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia', Schizophrenia Research, vol. 106, no. 2-3, pp. 208-217. https://doi.org/10.1016/j.schres.2008.07.022

Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. / Edwards, Todd L.; Wang, Xu; Chen, Qi; Wormly, Brandon; Riley, Brien; O'Neill, F. Anthony; Walsh, Dermot; Ritchie, Marylyn Deriggi; Kendler, Kenneth S.; Chen, Xiangning.

In: Schizophrenia Research, Vol. 106, No. 2-3, 01.12.2008, p. 208-217.

Research output: Contribution to journalArticle

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AU - Edwards, Todd L.

AU - Wang, Xu

AU - Chen, Qi

AU - Wormly, Brandon

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AU - Walsh, Dermot

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