Interaction between parathyroid hormone and endogenous estrogen in normal women

James R. Buchanan, Richard J. Santen, Anthony Cavaliere, Susanne W. Cauffman, Robert B. Greer, Laurence Demers

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

It has been hypothesized that estrogens conserve bone substance by blocking the resorbing effect of parathyroid hormone (PTH). We evaluated this hypothesis by examining the relation of circulating PTH to endogenous estrogen fluctuation during four quarters of a single menstrual cycle in 20 normal women. The hypothesis predicts that PTH should vary directly with estrogen, since PTH should increase following estrogen elevation to satisfy physiologic demands for calcium. Contrary to the predicted direct variation, PTH remained constant throughout the menstrual cycle despite sharply fluctuating estrogen levels. Furthermore, PTH was negatively associated with estrone during the early follicular (r = -.65, P < 0.005) and late follicular (r = -.84, P < 0.0001) phases. We attempted to determine whether this unexpected relationship between estrone and PTH signified a direct physiologic link, by excluding factors which could have spuriously engendered the inverse correlation. Stepwise multiple regression and partial correlation showed that estrone contributed significantly to circulating PTH independent of the effects of dietary calcium, 25-hydroxyvitamin D, serum calcium, 1,25-dihydroxyvitamin D, phosphate, estradiol, progesterone, and body weight. Therefore, it is possible that the inverse correlation between estrone and PTH signified a direct physiologic link, as an artifactual cause for the relationship could not be identified. These data imply that estrone interacts with PTH, but not by blocking PTH-mediated bone resorption. We conclude that estrone is associated with reduced circulating PTH through an as yet undetermined mechanism.

Original languageEnglish (US)
Pages (from-to)489-494
Number of pages6
JournalMetabolism
Volume35
Issue number6
DOIs
StatePublished - Jan 1 1986

Fingerprint

Parathyroid Hormone
Estrogens
Estrone
Menstrual Cycle
Calcium
Dietary Calcium
Bone Resorption
Progesterone
Estradiol
Phosphates
Body Weight
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Buchanan, J. R., Santen, R. J., Cavaliere, A., Cauffman, S. W., Greer, R. B., & Demers, L. (1986). Interaction between parathyroid hormone and endogenous estrogen in normal women. Metabolism, 35(6), 489-494. https://doi.org/10.1016/0026-0495(86)90003-X
Buchanan, James R. ; Santen, Richard J. ; Cavaliere, Anthony ; Cauffman, Susanne W. ; Greer, Robert B. ; Demers, Laurence. / Interaction between parathyroid hormone and endogenous estrogen in normal women. In: Metabolism. 1986 ; Vol. 35, No. 6. pp. 489-494.
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Buchanan, JR, Santen, RJ, Cavaliere, A, Cauffman, SW, Greer, RB & Demers, L 1986, 'Interaction between parathyroid hormone and endogenous estrogen in normal women', Metabolism, vol. 35, no. 6, pp. 489-494. https://doi.org/10.1016/0026-0495(86)90003-X

Interaction between parathyroid hormone and endogenous estrogen in normal women. / Buchanan, James R.; Santen, Richard J.; Cavaliere, Anthony; Cauffman, Susanne W.; Greer, Robert B.; Demers, Laurence.

In: Metabolism, Vol. 35, No. 6, 01.01.1986, p. 489-494.

Research output: Contribution to journalArticle

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Buchanan JR, Santen RJ, Cavaliere A, Cauffman SW, Greer RB, Demers L. Interaction between parathyroid hormone and endogenous estrogen in normal women. Metabolism. 1986 Jan 1;35(6):489-494. https://doi.org/10.1016/0026-0495(86)90003-X