Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children

Yang Zhou, Li Wen Hu, Zhengmin Qian, Sarah Dee Geiger, Katelyn L. Parrish, Shyamali C. Dharmage, Brittany Campbell, Marjut Roponen, Pasi Jalava, Maija Riitta Hirvonen, Joachim Heinrich, Xiao Wen Zeng, Bo Yi Yang, Xiao Di Qin, Yungling Leo Lee, Guang Hui Dong

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Abstract

To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009-2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents.

Original languageEnglish (US)
Article number1140
JournalScientific reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

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Gonadal Steroid Hormones
Asthma
Estradiol
Hormones
Confidence Intervals
Testosterone
Logistic Models
Taiwan
Biomarkers
Odds Ratio
Control Groups

All Science Journal Classification (ASJC) codes

  • General

Cite this

Zhou, Yang ; Hu, Li Wen ; Qian, Zhengmin ; Geiger, Sarah Dee ; Parrish, Katelyn L. ; Dharmage, Shyamali C. ; Campbell, Brittany ; Roponen, Marjut ; Jalava, Pasi ; Hirvonen, Maija Riitta ; Heinrich, Joachim ; Zeng, Xiao Wen ; Yang, Bo Yi ; Qin, Xiao Di ; Lee, Yungling Leo ; Dong, Guang Hui. / Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children. In: Scientific reports. 2017 ; Vol. 7, No. 1.
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title = "Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children",
abstract = "To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009-2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95{\%} Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95{\%} CI: 1.46, 11.06) among boys and 1.25 for PFOS (95{\%} CI: 0.84, 1.86) to 4.16 for PFNA (95{\%} CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents.",
author = "Yang Zhou and Hu, {Li Wen} and Zhengmin Qian and Geiger, {Sarah Dee} and Parrish, {Katelyn L.} and Dharmage, {Shyamali C.} and Brittany Campbell and Marjut Roponen and Pasi Jalava and Hirvonen, {Maija Riitta} and Joachim Heinrich and Zeng, {Xiao Wen} and Yang, {Bo Yi} and Qin, {Xiao Di} and Lee, {Yungling Leo} and Dong, {Guang Hui}",
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doi = "10.1038/s41598-017-01140-5",
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Zhou, Y, Hu, LW, Qian, Z, Geiger, SD, Parrish, KL, Dharmage, SC, Campbell, B, Roponen, M, Jalava, P, Hirvonen, MR, Heinrich, J, Zeng, XW, Yang, BY, Qin, XD, Lee, YL & Dong, GH 2017, 'Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children', Scientific reports, vol. 7, no. 1, 1140. https://doi.org/10.1038/s41598-017-01140-5

Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children. / Zhou, Yang; Hu, Li Wen; Qian, Zhengmin; Geiger, Sarah Dee; Parrish, Katelyn L.; Dharmage, Shyamali C.; Campbell, Brittany; Roponen, Marjut; Jalava, Pasi; Hirvonen, Maija Riitta; Heinrich, Joachim; Zeng, Xiao Wen; Yang, Bo Yi; Qin, Xiao Di; Lee, Yungling Leo; Dong, Guang Hui.

In: Scientific reports, Vol. 7, No. 1, 1140, 01.12.2017.

Research output: Contribution to journalArticle

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T1 - Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children

AU - Zhou, Yang

AU - Hu, Li Wen

AU - Qian, Zhengmin

AU - Geiger, Sarah Dee

AU - Parrish, Katelyn L.

AU - Dharmage, Shyamali C.

AU - Campbell, Brittany

AU - Roponen, Marjut

AU - Jalava, Pasi

AU - Hirvonen, Maija Riitta

AU - Heinrich, Joachim

AU - Zeng, Xiao Wen

AU - Yang, Bo Yi

AU - Qin, Xiao Di

AU - Lee, Yungling Leo

AU - Dong, Guang Hui

PY - 2017/12/1

Y1 - 2017/12/1

N2 - To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009-2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents.

AB - To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009-2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents.

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