Interactions between growth factor secretion and polyamines in MCF-7 Breast Cancer Cells

Fredric J. Cohen, Andrea Manni, Patricia Glikman, Mary Bartholomew, Laurence Demers

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Polyamines may be involved in hormone-dependent breast cancer cell proliferation. The antiestrogen 4-hydroxytamoxifen and the polyamine synthesis inhibitor α-difluoromethylornithine (DFMO) inhibited MCF-7 growth, and this effect was additive. Transforming growth factor β (TGF-β) levels were increased by both compounds; again the effect was additive. Exogenous putrescine antagonized DFMO but not the antiestrogen. However, exogenous TGF-β did not inhibit cell growth. Secretion of insulin-like growth factor 1 (IGF-1) was not affected by DFMO-induced polyamine depletion but 4-hydroxytamoxifen increased IGF-1, which suggests an estradiol-like effect. Thus polyamines are involved in basal TGF-β secretion but do not mediate antiestrogen-induced TGF-β secretion. IGF-1 secretion by MCF-7 cells is not under polyamine control. The antiproliferative effects of 4-hydroxytamoxifen and DFMO cannot be accounted for by either suppression of IGF-1 secretion (a growth stimulatory factor) or stimulation of TGF-β production (a growth inhibitory polypeptide).

Original languageEnglish (US)
Pages (from-to)603-608
Number of pages6
JournalEuropean Journal of Cancer and Clinical Oncology
Volume26
Issue number5
DOIs
StatePublished - Jan 1 1990

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Polyamines
Eflornithine
Transforming Growth Factors
Somatomedins
Intercellular Signaling Peptides and Proteins
Estrogen Receptor Modulators
Breast Neoplasms
Growth
Putrescine
MCF-7 Cells
Estradiol
Cell Proliferation
Hormones
Peptides
afimoxifene

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Cohen, Fredric J. ; Manni, Andrea ; Glikman, Patricia ; Bartholomew, Mary ; Demers, Laurence. / Interactions between growth factor secretion and polyamines in MCF-7 Breast Cancer Cells. In: European Journal of Cancer and Clinical Oncology. 1990 ; Vol. 26, No. 5. pp. 603-608.
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Interactions between growth factor secretion and polyamines in MCF-7 Breast Cancer Cells. / Cohen, Fredric J.; Manni, Andrea; Glikman, Patricia; Bartholomew, Mary; Demers, Laurence.

In: European Journal of Cancer and Clinical Oncology, Vol. 26, No. 5, 01.01.1990, p. 603-608.

Research output: Contribution to journalArticle

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