Interakcje herbicydów i niektórych najcześciej stosowanych grup leków. I. Interakcje herbicydów

Karbendazymu, kwasu 2,4-dichlorofenoksyoctowego i kwasu 2,4,5-trichlorofenoksyoctowego podawanych przewlekle z lekami działajacymi na układ krazenia.

Translated title of the contribution: Interactions between herbicides and various of the most frequently used drug groups. I. Interactions between chronically administered herbicides: carbendazyme, 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid and drugs affecting the circulatory system

Piotr Janicki, E. A. Paulo, W. Pasierbski, Z. Rutczyńska, Z. Szreniawski

Research output: Contribution to journalArticle

Abstract

The influence of chronically administered (6 weeks) herbicides (KAR, 2,4-D and 2,4,5-T) on pharmacological effects of quinidine, reserpine and strophantin K in mice and rats was examined in vivo. The investigated herbicides produced in mice an increase in acute toxicity of strophantin K, the acute toxicity of either reserpine oro quinidine being unchanged. The herbicides alone, after 6 weeks administration, significantly increased mean arterial pressure of rats, however the hypotensive response to reserpine was not statistically influenced in these animals as compared with controls. The prolonged administration of investigated herbicides produced also the increased sensibility of heart to the arrhythmic effects of quinidine and ouabain as observed in the ecg pattern in rats treated with increasing doses of these agents. The studies indicate the significance of the possible pharmacological interactions between the drugs affecting cardiovascular system and commonly used herbicides in men.

Original languagePolish
Pages (from-to)167-174
Number of pages8
JournalMedycyna Pracy
Volume37
Issue number3
StatePublished - 1986

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2,4,5-Trichlorophenoxyacetic Acid
2,4-Dichlorophenoxyacetic Acid
Herbicides
Cardiovascular System
Quinidine
Reserpine
Pharmaceutical Preparations
Pharmacology
Ouabain
Drug Interactions
Arterial Pressure
carbendazim

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Interakcje herbicyd{\'o}w i niekt{\'o}rych najcześciej stosowanych grup lek{\'o}w. I. Interakcje herbicyd{\'o}w: Karbendazymu, kwasu 2,4-dichlorofenoksyoctowego i kwasu 2,4,5-trichlorofenoksyoctowego podawanych przewlekle z lekami działajacymi na układ krazenia.",
abstract = "The influence of chronically administered (6 weeks) herbicides (KAR, 2,4-D and 2,4,5-T) on pharmacological effects of quinidine, reserpine and strophantin K in mice and rats was examined in vivo. The investigated herbicides produced in mice an increase in acute toxicity of strophantin K, the acute toxicity of either reserpine oro quinidine being unchanged. The herbicides alone, after 6 weeks administration, significantly increased mean arterial pressure of rats, however the hypotensive response to reserpine was not statistically influenced in these animals as compared with controls. The prolonged administration of investigated herbicides produced also the increased sensibility of heart to the arrhythmic effects of quinidine and ouabain as observed in the ecg pattern in rats treated with increasing doses of these agents. The studies indicate the significance of the possible pharmacological interactions between the drugs affecting cardiovascular system and commonly used herbicides in men.",
author = "Piotr Janicki and Paulo, {E. A.} and W. Pasierbski and Z. Rutczyńska and Z. Szreniawski",
year = "1986",
language = "Polish",
volume = "37",
pages = "167--174",
journal = "Medycyna Pracy",
issn = "0465-5893",
publisher = "Nofer Institute of Occupational Medicine",
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}

TY - JOUR

T1 - Interakcje herbicydów i niektórych najcześciej stosowanych grup leków. I. Interakcje herbicydów

T2 - Karbendazymu, kwasu 2,4-dichlorofenoksyoctowego i kwasu 2,4,5-trichlorofenoksyoctowego podawanych przewlekle z lekami działajacymi na układ krazenia.

AU - Janicki, Piotr

AU - Paulo, E. A.

AU - Pasierbski, W.

AU - Rutczyńska, Z.

AU - Szreniawski, Z.

PY - 1986

Y1 - 1986

N2 - The influence of chronically administered (6 weeks) herbicides (KAR, 2,4-D and 2,4,5-T) on pharmacological effects of quinidine, reserpine and strophantin K in mice and rats was examined in vivo. The investigated herbicides produced in mice an increase in acute toxicity of strophantin K, the acute toxicity of either reserpine oro quinidine being unchanged. The herbicides alone, after 6 weeks administration, significantly increased mean arterial pressure of rats, however the hypotensive response to reserpine was not statistically influenced in these animals as compared with controls. The prolonged administration of investigated herbicides produced also the increased sensibility of heart to the arrhythmic effects of quinidine and ouabain as observed in the ecg pattern in rats treated with increasing doses of these agents. The studies indicate the significance of the possible pharmacological interactions between the drugs affecting cardiovascular system and commonly used herbicides in men.

AB - The influence of chronically administered (6 weeks) herbicides (KAR, 2,4-D and 2,4,5-T) on pharmacological effects of quinidine, reserpine and strophantin K in mice and rats was examined in vivo. The investigated herbicides produced in mice an increase in acute toxicity of strophantin K, the acute toxicity of either reserpine oro quinidine being unchanged. The herbicides alone, after 6 weeks administration, significantly increased mean arterial pressure of rats, however the hypotensive response to reserpine was not statistically influenced in these animals as compared with controls. The prolonged administration of investigated herbicides produced also the increased sensibility of heart to the arrhythmic effects of quinidine and ouabain as observed in the ecg pattern in rats treated with increasing doses of these agents. The studies indicate the significance of the possible pharmacological interactions between the drugs affecting cardiovascular system and commonly used herbicides in men.

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