Abstract
Agonist-evoked, intracellular Ca2+-signalling events are associated with active extrusion of Ca2+ across the plasrna membrane, implying a local increase in Ca2+ concentration ([Ca2+]) at the extracellular face of the cell. The possibility that these external [Ca2+] changes may have specific physiological functions has received little consideration in the past. Here we show that physiological ambient [Ca2+], Ca2+ mobilization in one cell produces an extracellular signal that can be detected in nearby cells expressing the extracellular Ca2+-sensing receptor (CaR), a cell-surface receptor for divalent cations wth a widespread tissue distribution. The CaR may therefore mediate a universal form of intercellular communication that allows cells to be informed of the Ca2+-signalling status of their neighbours.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 392-398 |
| Number of pages | 7 |
| Journal | Nature Cell Biology |
| Volume | 2 |
| Issue number | 7 |
| DOIs | |
| State | Published - Oct 30 2000 |
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All Science Journal Classification (ASJC) codes
- Cell Biology
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Intercellular communication mediated by the extracellular calcium-sensing receptor. / Hofer, Aldebaran M.; Curci, Silvana; Doble, Marc A.; Brown, Edward M.; Soybel, David.
In: Nature Cell Biology, Vol. 2, No. 7, 30.10.2000, p. 392-398.Research output: Contribution to journal › Article
TY - JOUR
T1 - Intercellular communication mediated by the extracellular calcium-sensing receptor
AU - Hofer, Aldebaran M.
AU - Curci, Silvana
AU - Doble, Marc A.
AU - Brown, Edward M.
AU - Soybel, David
PY - 2000/10/30
Y1 - 2000/10/30
N2 - Agonist-evoked, intracellular Ca2+-signalling events are associated with active extrusion of Ca2+ across the plasrna membrane, implying a local increase in Ca2+ concentration ([Ca2+]) at the extracellular face of the cell. The possibility that these external [Ca2+] changes may have specific physiological functions has received little consideration in the past. Here we show that physiological ambient [Ca2+], Ca2+ mobilization in one cell produces an extracellular signal that can be detected in nearby cells expressing the extracellular Ca2+-sensing receptor (CaR), a cell-surface receptor for divalent cations wth a widespread tissue distribution. The CaR may therefore mediate a universal form of intercellular communication that allows cells to be informed of the Ca2+-signalling status of their neighbours.
AB - Agonist-evoked, intracellular Ca2+-signalling events are associated with active extrusion of Ca2+ across the plasrna membrane, implying a local increase in Ca2+ concentration ([Ca2+]) at the extracellular face of the cell. The possibility that these external [Ca2+] changes may have specific physiological functions has received little consideration in the past. Here we show that physiological ambient [Ca2+], Ca2+ mobilization in one cell produces an extracellular signal that can be detected in nearby cells expressing the extracellular Ca2+-sensing receptor (CaR), a cell-surface receptor for divalent cations wth a widespread tissue distribution. The CaR may therefore mediate a universal form of intercellular communication that allows cells to be informed of the Ca2+-signalling status of their neighbours.
UR - http://www.scopus.com/inward/record.url?scp=0033776185&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033776185&partnerID=8YFLogxK
U2 - 10.1038/35017020
DO - 10.1038/35017020
M3 - Article
C2 - 10878803
AN - SCOPUS:0033776185
VL - 2
SP - 392
EP - 398
JO - Nature Cell Biology
JF - Nature Cell Biology
SN - 1465-7392
IS - 7
ER -