Analyse du peptide natriurétique de type B comme marqueur du cœur pulmonaire aigu dans le syndrome de détresse respiratoire aiguë

Translated title of the contribution: Interest of the brain natriuretic peptide as a marker of acute cor pulmonale in acute respiratory distress syndrome

S. Thierry, L. Lecuyer, E. Brocas, A. Van de Louw, S. Hours, M. H. Moreau, R. Boiteau, A. Tenaillon

Research output: Contribution to journalArticle

7 Scopus citations


Objective: The aim of this study was to evaluate the accuracy of the BNP as a marker of acute cor pulmonale in patients with ARDS. Study design: Prospective clinical trial. Patients and methods: At day 2 or 3 after the onset of the ARDS, an echocardiography was performed. Patients with left ventricular dysfunction were excluded. Right ventricular area (RVA) and RVA/LVA ratio were measured. ACP was defined as RVA/LVA > 0.6 associated with septal dyskinesia. Simultaneously, 5 ml of blood was collected for BNP measurement. Results: 26 patients were studied. BNP levels were higher in 10 patients with ACP: 585.5 [189-4830] vs 145.5 [36.5-346] pg/ml (P = 0.01) but in those with creatinine clearance < 90 ml/min: 602 [331-3530] vs 125 [39-189] pg/ml (P = 0.007). BNP was correlated with RVA (r = 0.5; p = 0.01), RVA/LVA ratio (r = 0.61; p = 0.001), sPAP (r = 0.58; p = 0.002) and with age, cardiac index and creatinine clearance (r = 0.61; p = 0.001). In multivariate analysis, BNP was only correlated with creatinine clearance (p = 0.03), and RVA (p = 0.06). Conclusion: In ARDS patients without left ventricular dysfunction, BNP level is more elevated in patients with acute cor pulmonale than patients without cor pulmonale.

Original languageFrench
Pages (from-to)815-819
Number of pages5
JournalAnnales Francaises d'Anesthesie et de Reanimation
Issue number8
Publication statusPublished - Aug 1 2006


All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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