Interferon-induced growth arrest is mediated by membrane structural changes

A. Guha, R. P. Mason, D. Primorac, G. Konopaske, J. Miller, P. Sinha, T. N. Tulenko, A. Hand

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Interferon-γ (IFN-γ,) is an immunomodulator shown to augment the expression of major histocompatibility (MHC) class I/class II antigens on the cell surface. In previous studies, we have demonstrated that the enhanced expression of these antigens on the cell surface is in part due to IFN-γ- mediated abrogation of antigen shedding. In this study, we demonstrate that IFN-γ induces structural changes in the cell membrane by altering the cholesterol/phospholipid ratio. Furthermore, such changes not only mediate enhanced expression of antigen on the cell surface but may drive the cells to growth arrest and apoptosis. These results were obtained by employing x-ray diffraction, electron microscopy, and DNA analysis.

Original languageEnglish (US)
Pages (from-to)701-706
Number of pages6
JournalJournal of Interferon and Cytokine Research
Volume17
Issue number11
StatePublished - Nov 1 1997

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Surface Antigens
Interferons
Histocompatibility
Membranes
Histocompatibility Antigens Class II
Immunologic Factors
Growth
Transmission Electron Microscopy
Phospholipids
Cholesterol
Cell Membrane
X-Rays
Apoptosis
Antigens
DNA

All Science Journal Classification (ASJC) codes

  • Immunology
  • Cell Biology
  • Virology

Cite this

Guha, A., Mason, R. P., Primorac, D., Konopaske, G., Miller, J., Sinha, P., ... Hand, A. (1997). Interferon-induced growth arrest is mediated by membrane structural changes. Journal of Interferon and Cytokine Research, 17(11), 701-706.
Guha, A. ; Mason, R. P. ; Primorac, D. ; Konopaske, G. ; Miller, J. ; Sinha, P. ; Tulenko, T. N. ; Hand, A. / Interferon-induced growth arrest is mediated by membrane structural changes. In: Journal of Interferon and Cytokine Research. 1997 ; Vol. 17, No. 11. pp. 701-706.
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Guha, A, Mason, RP, Primorac, D, Konopaske, G, Miller, J, Sinha, P, Tulenko, TN & Hand, A 1997, 'Interferon-induced growth arrest is mediated by membrane structural changes', Journal of Interferon and Cytokine Research, vol. 17, no. 11, pp. 701-706.

Interferon-induced growth arrest is mediated by membrane structural changes. / Guha, A.; Mason, R. P.; Primorac, D.; Konopaske, G.; Miller, J.; Sinha, P.; Tulenko, T. N.; Hand, A.

In: Journal of Interferon and Cytokine Research, Vol. 17, No. 11, 01.11.1997, p. 701-706.

Research output: Contribution to journalArticle

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AU - Guha, A.

AU - Mason, R. P.

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AU - Sinha, P.

AU - Tulenko, T. N.

AU - Hand, A.

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AB - Interferon-γ (IFN-γ,) is an immunomodulator shown to augment the expression of major histocompatibility (MHC) class I/class II antigens on the cell surface. In previous studies, we have demonstrated that the enhanced expression of these antigens on the cell surface is in part due to IFN-γ- mediated abrogation of antigen shedding. In this study, we demonstrate that IFN-γ induces structural changes in the cell membrane by altering the cholesterol/phospholipid ratio. Furthermore, such changes not only mediate enhanced expression of antigen on the cell surface but may drive the cells to growth arrest and apoptosis. These results were obtained by employing x-ray diffraction, electron microscopy, and DNA analysis.

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Guha A, Mason RP, Primorac D, Konopaske G, Miller J, Sinha P et al. Interferon-induced growth arrest is mediated by membrane structural changes. Journal of Interferon and Cytokine Research. 1997 Nov 1;17(11):701-706.