Interferon-induced growth arrest is mediated by membrane structural changes

A. Guha, R. P. Mason, D. Primorac, G. Konopaske, J. Miller, P. Sinha, T. N. Tulenko, A. Hand

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Interferon-γ (IFN-γ,) is an immunomodulator shown to augment the expression of major histocompatibility (MHC) class I/class II antigens on the cell surface. In previous studies, we have demonstrated that the enhanced expression of these antigens on the cell surface is in part due to IFN-γ- mediated abrogation of antigen shedding. In this study, we demonstrate that IFN-γ induces structural changes in the cell membrane by altering the cholesterol/phospholipid ratio. Furthermore, such changes not only mediate enhanced expression of antigen on the cell surface but may drive the cells to growth arrest and apoptosis. These results were obtained by employing x-ray diffraction, electron microscopy, and DNA analysis.

Original languageEnglish (US)
Pages (from-to)701-706
Number of pages6
JournalJournal of Interferon and Cytokine Research
Volume17
Issue number11
DOIs
StatePublished - Nov 1997

All Science Journal Classification (ASJC) codes

  • Immunology
  • Cell Biology
  • Virology

Fingerprint Dive into the research topics of 'Interferon-induced growth arrest is mediated by membrane structural changes'. Together they form a unique fingerprint.

  • Cite this

    Guha, A., Mason, R. P., Primorac, D., Konopaske, G., Miller, J., Sinha, P., Tulenko, T. N., & Hand, A. (1997). Interferon-induced growth arrest is mediated by membrane structural changes. Journal of Interferon and Cytokine Research, 17(11), 701-706. https://doi.org/10.1089/jir.1997.17.701