@article{753a4e4586f34db3b0a5018fa5d3c8a9,
title = "Interindividual differences in attentional vulnerability moderate cognitive performance during sleep restriction and subsequent recovery in healthy young men",
abstract = "We investigated whether interindividual attentional vulnerability moderates performance on domain-specific cognitive tasks during sleep restriction (SR) and subsequent recovery sleep. Fifteen healthy men (M ± SD, 22.3 ± 2.8 years) were exposed to three nights of baseline, five nights of 5-h time in bed SR, and two nights of recovery sleep. Participants completed tasks assessing working memory, visuospatial processing, and processing speed approximately every two hours during wake. Analyses examined performance across SR and recovery (linear predictor day or quadratic predictor day2) moderated by attentional vulnerability per participant (difference between mean psychomotor vigilance task lapses after the fifth SR night versus the last baseline night). For significant interactions between day/day2 and vulnerability, we investigated the effect of day/day2 at 1 SD below (less vulnerable level) and above (more vulnerable level) the mean of attentional vulnerability (N = 15 in all analyses). Working memory accuracy and speed on the Fractal 2-Back and visuospatial processing speed and efficiency on the Line Orientation Task improved across the entire study at the less vulnerable level (mean − 1SD) but not the more vulnerable level (mean + 1SD). Therefore, vulnerability to attentional lapses after SR is a marker of susceptibility to working memory and visuospatial processing impairment during SR and subsequent recovery.",
author = "Mathew, {Gina Marie} and Strayer, {Stephen M.} and Ness, {Kelly M.} and Schade, {Margeaux M.} and Nahmod, {Nicole G.} and Buxton, {Orfeu M.} and Chang, {Anne Marie}",
note = "Funding Information: This study was supported by the Clinical and Translational Science Institute (PI: A-M.C.) and by funds from the College of Health and Human Development at the Pennsylvania State University (to A-M.C. and O.M.B.). The Clinical Research Center is supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through grants UL1 TR002014 and UL1 TR00045. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Funding Information: The authors declare no competing interests. Outside of the current work, O.M.B. received subcontract grants to Pennsylvania State University from Proactive Life (formerly Mobile Sleep Technologies) doing business as SleepSpace (National Science Foundation Grant #1622766 and NIH/National Institute on Aging Small Business Innovation Research Program R43AG056250, R44 AG056250), honoraria/travel support for lectures from Boston University, Boston College, Tufts School of Dental Medicine, Harvard Chan School of Public Health, New York University, and Allstate, consulting fees from Sleep Number, and an honorarium for his role as the Editor-in-Chief of Sleep Health (sleephealthjournal.org). Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = dec,
doi = "10.1038/s41598-021-95884-w",
language = "English (US)",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}