Interleukin-13: A promising therapeutic target for autoimmune disease

Yan Mei Mao, Chan Na Zhao, Jing Leng, Rui Xue Leng, Dong Qing Ye, Song Guo Zheng, Hai Feng Pan

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Interleukin-13 (IL-13) was previously thought to be a redundant presence of IL-4, but in recent years its role in immunity, inflammation, fibrosis, and allergic diseases has become increasingly prominent. IL-13 can regulate several subtypes of T helper (Th) cells and affect their transformation, including Th1, Th2, T17, etc., thus it may play an important role in immune system. Previous studies have revealed that IL-13 is implicated in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), ulcerative colitis (UC), type 1 diabetes (T1D), sjogren's syndrome (SS), etc. In this review, we will briefly discuss the biological features of IL-13 and summarize recent advances in the role of IL-13 in the development and pathogenesis of autoimmune diseases. This information may provide new perspectives and suggestions for the selection of therapeutic targets for autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)9-23
Number of pages15
JournalCytokine and Growth Factor Reviews
Volume45
DOIs
StatePublished - Feb 1 2019

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Interleukin-13
Autoimmune Diseases
Therapeutics
Systemic Scleroderma
Immune system
Sjogren's Syndrome
Medical problems
Helper-Inducer T-Lymphocytes
Type 1 Diabetes Mellitus
Ulcerative Colitis
Interleukin-4
Systemic Lupus Erythematosus
Immune System
Immunity
Rheumatoid Arthritis
Fibrosis
Inflammation

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mao, Y. M., Zhao, C. N., Leng, J., Leng, R. X., Ye, D. Q., Zheng, S. G., & Pan, H. F. (2019). Interleukin-13: A promising therapeutic target for autoimmune disease. Cytokine and Growth Factor Reviews, 45, 9-23. https://doi.org/10.1016/j.cytogfr.2018.12.001
Mao, Yan Mei ; Zhao, Chan Na ; Leng, Jing ; Leng, Rui Xue ; Ye, Dong Qing ; Zheng, Song Guo ; Pan, Hai Feng. / Interleukin-13 : A promising therapeutic target for autoimmune disease. In: Cytokine and Growth Factor Reviews. 2019 ; Vol. 45. pp. 9-23.
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Interleukin-13 : A promising therapeutic target for autoimmune disease. / Mao, Yan Mei; Zhao, Chan Na; Leng, Jing; Leng, Rui Xue; Ye, Dong Qing; Zheng, Song Guo; Pan, Hai Feng.

In: Cytokine and Growth Factor Reviews, Vol. 45, 01.02.2019, p. 9-23.

Research output: Contribution to journalReview article

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T2 - A promising therapeutic target for autoimmune disease

AU - Mao, Yan Mei

AU - Zhao, Chan Na

AU - Leng, Jing

AU - Leng, Rui Xue

AU - Ye, Dong Qing

AU - Zheng, Song Guo

AU - Pan, Hai Feng

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