Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa

Shilpa Jain-Vora, Ann Marie Levine, Zissis Chroneos, Gary F. Ross, William M. Hull, Jeffrey A. Whitsett

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

To determine the effects of interleukin-4 (IL-4) on bacterial clearance from the mouse lung, transgenic mice expressing IL-4 in respiratory epithelial cells under the control of the Clara cell secretory protein promoter (CCSP-IL-4 mice) were infected intratracheally with Pseudomonas aeruginosa. Survival of CCSP-IL-4 mice following bacterial administration was markedly improved compared with that of control mice. While bacteria proliferated in lungs of wild-type mice, a rapid reduction in the number of bacteria was observed in the IL-4 mice as early as 6 h postinfection. Similarly, intranasal administration of IL-4 enhanced bacterial clearance from the lungs of wild-type mice. While acute and chronic IL-4 increased the numbers of neutrophils in bronchoalveolar lavage fluid, bacterial infection was associated with acute neutrophilic pulmonary infiltration, and this response was similar in the presence or absence of IL-4. Local administration or expression of IL-4 in the mouse lung enhanced pulmonary clearance of P. aeruginosa in vivo and decreased mortality following infection.

Original languageEnglish (US)
Pages (from-to)4229-4236
Number of pages8
JournalInfection and Immunity
Volume66
Issue number9
StatePublished - Sep 9 1998

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Interleukin-4
Pseudomonas aeruginosa
Lung
Uteroglobin
Bacteria
Intranasal Administration
Bronchoalveolar Lavage Fluid
Bacterial Infections
Transgenic Mice
Neutrophils
Epithelial Cells
Mortality
Infection

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Jain-Vora, S., Levine, A. M., Chroneos, Z., Ross, G. F., Hull, W. M., & Whitsett, J. A. (1998). Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa. Infection and Immunity, 66(9), 4229-4236.
Jain-Vora, Shilpa ; Levine, Ann Marie ; Chroneos, Zissis ; Ross, Gary F. ; Hull, William M. ; Whitsett, Jeffrey A. / Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa. In: Infection and Immunity. 1998 ; Vol. 66, No. 9. pp. 4229-4236.
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Jain-Vora, S, Levine, AM, Chroneos, Z, Ross, GF, Hull, WM & Whitsett, JA 1998, 'Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa', Infection and Immunity, vol. 66, no. 9, pp. 4229-4236.

Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa. / Jain-Vora, Shilpa; Levine, Ann Marie; Chroneos, Zissis; Ross, Gary F.; Hull, William M.; Whitsett, Jeffrey A.

In: Infection and Immunity, Vol. 66, No. 9, 09.09.1998, p. 4229-4236.

Research output: Contribution to journalArticle

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Jain-Vora S, Levine AM, Chroneos Z, Ross GF, Hull WM, Whitsett JA. Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa. Infection and Immunity. 1998 Sep 9;66(9):4229-4236.