Intermediate filament assembly: dynamics to disease

Lisa M. Godsel, Ryan Hobbs, Kathleen J. Green

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

Intermediate filament (IF) proteins belong to a large and diverse gene family with broad representation in vertebrate tissues. Although considered the 'toughest' cytoskeletal fibers, studies in cultured cells have revealed that IF can be surprisingly dynamic and highly regulated. This review examines the diversity of IF assembly behaviors, and considers the ideas that IF proteins are co- or post-translationally assembled into oligomeric precursors, which can be delivered to different subcellular compartments by microtubules or actomyosin and associated motor proteins. Their interaction with other cellular elements via IF associated proteins (IFAPs) affects IF dynamics and also results in cellular networks with properties that transcend those of individual components. We end by discussing how mutations leading to defects in IF assembly, network formation or IF-IFAP association compromise in vivo functions of IF as protectors against environmental stress.

Original languageEnglish (US)
Pages (from-to)28-37
Number of pages10
JournalTrends in Cell Biology
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2008

Fingerprint

Intermediate Filaments
Intermediate Filament Proteins
Actomyosin
Microtubules
Vertebrates
Cultured Cells
Proteins
Mutation
Genes

All Science Journal Classification (ASJC) codes

  • Cell Biology

Cite this

Godsel, Lisa M. ; Hobbs, Ryan ; Green, Kathleen J. / Intermediate filament assembly : dynamics to disease. In: Trends in Cell Biology. 2008 ; Vol. 18, No. 1. pp. 28-37.
@article{f7e47fc0aefa469383c49594da07e472,
title = "Intermediate filament assembly: dynamics to disease",
abstract = "Intermediate filament (IF) proteins belong to a large and diverse gene family with broad representation in vertebrate tissues. Although considered the 'toughest' cytoskeletal fibers, studies in cultured cells have revealed that IF can be surprisingly dynamic and highly regulated. This review examines the diversity of IF assembly behaviors, and considers the ideas that IF proteins are co- or post-translationally assembled into oligomeric precursors, which can be delivered to different subcellular compartments by microtubules or actomyosin and associated motor proteins. Their interaction with other cellular elements via IF associated proteins (IFAPs) affects IF dynamics and also results in cellular networks with properties that transcend those of individual components. We end by discussing how mutations leading to defects in IF assembly, network formation or IF-IFAP association compromise in vivo functions of IF as protectors against environmental stress.",
author = "Godsel, {Lisa M.} and Ryan Hobbs and Green, {Kathleen J.}",
year = "2008",
month = "1",
day = "1",
doi = "10.1016/j.tcb.2007.11.004",
language = "English (US)",
volume = "18",
pages = "28--37",
journal = "Trends in Cell Biology",
issn = "0962-8924",
publisher = "Elsevier Limited",
number = "1",

}

Intermediate filament assembly : dynamics to disease. / Godsel, Lisa M.; Hobbs, Ryan; Green, Kathleen J.

In: Trends in Cell Biology, Vol. 18, No. 1, 01.01.2008, p. 28-37.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Intermediate filament assembly

T2 - dynamics to disease

AU - Godsel, Lisa M.

AU - Hobbs, Ryan

AU - Green, Kathleen J.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Intermediate filament (IF) proteins belong to a large and diverse gene family with broad representation in vertebrate tissues. Although considered the 'toughest' cytoskeletal fibers, studies in cultured cells have revealed that IF can be surprisingly dynamic and highly regulated. This review examines the diversity of IF assembly behaviors, and considers the ideas that IF proteins are co- or post-translationally assembled into oligomeric precursors, which can be delivered to different subcellular compartments by microtubules or actomyosin and associated motor proteins. Their interaction with other cellular elements via IF associated proteins (IFAPs) affects IF dynamics and also results in cellular networks with properties that transcend those of individual components. We end by discussing how mutations leading to defects in IF assembly, network formation or IF-IFAP association compromise in vivo functions of IF as protectors against environmental stress.

AB - Intermediate filament (IF) proteins belong to a large and diverse gene family with broad representation in vertebrate tissues. Although considered the 'toughest' cytoskeletal fibers, studies in cultured cells have revealed that IF can be surprisingly dynamic and highly regulated. This review examines the diversity of IF assembly behaviors, and considers the ideas that IF proteins are co- or post-translationally assembled into oligomeric precursors, which can be delivered to different subcellular compartments by microtubules or actomyosin and associated motor proteins. Their interaction with other cellular elements via IF associated proteins (IFAPs) affects IF dynamics and also results in cellular networks with properties that transcend those of individual components. We end by discussing how mutations leading to defects in IF assembly, network formation or IF-IFAP association compromise in vivo functions of IF as protectors against environmental stress.

UR - http://www.scopus.com/inward/record.url?scp=37849013303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37849013303&partnerID=8YFLogxK

U2 - 10.1016/j.tcb.2007.11.004

DO - 10.1016/j.tcb.2007.11.004

M3 - Review article

C2 - 18083519

AN - SCOPUS:37849013303

VL - 18

SP - 28

EP - 37

JO - Trends in Cell Biology

JF - Trends in Cell Biology

SN - 0962-8924

IS - 1

ER -