@article{191b065f3e74423684251f0b2717d02f,
title = "Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota",
abstract = "While activation of beige thermogenesis is a promising approach for treatment of obesity-associated diseases, there are currently no known pharmacological means of inducing beiging in humans. Intermittent fasting is an effective and natural strategy for weight control, but the mechanism for its efficacy is poorly understood. Here, we show that an every-other-day fasting (EODF) regimen selectively stimulates beige fat development within white adipose tissue and dramatically ameliorates obesity, insulin resistance, and hepatic steatosis. EODF treatment results in a shift in the gut microbiota composition leading to elevation of the fermentation products acetate and lactate and to the selective upregulation of monocarboxylate transporter 1 expression in beige cells. Microbiota-depleted mice are resistance to EODF-induced beiging, while transplantation of the microbiota from EODF-treated mice to microbiota-depleted mice activates beiging and improves metabolic homeostasis. These findings provide a new gut-microbiota-driven mechanism for activating adipose tissue browning and treating metabolic diseases. White adipose beiging is a promising therapy for obesity and related metabolic diseases. Here, Li, Xie and colleagues find that an EODF regimen can selectively induce the beiging of white adipose tissue and subsequently ameliorate metabolic disorders in mice. Gut microbiota orchestrate the effects of EODF on beiging and metabolic improvement.",
author = "Guolin Li and Cen Xie and Siyu Lu and Nichols, {Robert G.} and Yuan Tian and Licen Li and Daxeshkumar Patel and Yinyan Ma and Brocker, {Chad N.} and Tingting Yan and Krausz, {Kristopher W.} and Rong Xiang and Oksana Gavrilova and Patterson, {Andrew D.} and Gonzalez, {Frank J.}",
note = "Funding Information: We thank Linda G. Byrd for technical assistance with the mouse studies. We thank Dongxue Sun, Jiang Yue, Jie Zhao, Lei Chen, Qiao Wang, Qiong Wang, Qiu Wang, Weiwei Liu, Xiaoxia Gao, Xianqiong Gong, Yoshinori Takizawa, Youbo Zhang, and Yuhong Luo for help with the mouse studies. This work was funded by the National Cancer Institute Intramural Research Program (ZIA BC005562), the National Institutes of Environmental Health Sciences (ES022186, to A.D.P.), the National Natural Science Funds of China (31271257, 9164910027, and 81403007), the Science and Technology Project of Hunan Province (2013FJ2001), and the Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province (20134486). G.L. was supported by a fellowship from the Chinese Scholarship Council (201406725005). The funding sponsors had no role in the design; in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. Funding Information: We thank Linda G. Byrd for technical assistance with the mouse studies. We thank Dongxue Sun, Jiang Yue, Jie Zhao, Lei Chen, Qiao Wang, Qiong Wang, Qiu Wang, Weiwei Liu, Xiaoxia Gao, Xianqiong Gong, Yoshinori Takizawa, Youbo Zhang, and Yuhong Luo for help with the mouse studies. This work was funded by the National Cancer Institute Intramural Research Program ( ZIA BC005562 ), the National Institutes of Environmental Health Sciences ( ES022186 , to A.D.P.), the National Natural Science Funds of China ( 31271257 , 9164910027 , and 81403007 ), the Science and Technology Project of Hunan Province ( 2013FJ2001 ), and the Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province ( 20134486 ). G.L. was supported by a fellowship from the Chinese Scholarship Council ( 201406725005 ). The funding sponsors had no role in the design; in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2017",
year = "2017",
month = oct,
day = "3",
doi = "10.1016/j.cmet.2017.08.019",
language = "English (US)",
volume = "26",
pages = "672--685.e4",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "4",
}
