Abstract
While activation of beige thermogenesis is a promising approach for treatment of obesity-associated diseases, there are currently no known pharmacological means of inducing beiging in humans. Intermittent fasting is an effective and natural strategy for weight control, but the mechanism for its efficacy is poorly understood. Here, we show that an every-other-day fasting (EODF) regimen selectively stimulates beige fat development within white adipose tissue and dramatically ameliorates obesity, insulin resistance, and hepatic steatosis. EODF treatment results in a shift in the gut microbiota composition leading to elevation of the fermentation products acetate and lactate and to the selective upregulation of monocarboxylate transporter 1 expression in beige cells. Microbiota-depleted mice are resistance to EODF-induced beiging, while transplantation of the microbiota from EODF-treated mice to microbiota-depleted mice activates beiging and improves metabolic homeostasis. These findings provide a new gut-microbiota-driven mechanism for activating adipose tissue browning and treating metabolic diseases. White adipose beiging is a promising therapy for obesity and related metabolic diseases. Here, Li, Xie and colleagues find that an EODF regimen can selectively induce the beiging of white adipose tissue and subsequently ameliorate metabolic disorders in mice. Gut microbiota orchestrate the effects of EODF on beiging and metabolic improvement.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 672-685.e4 |
| Journal | Cell Metabolism |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 3 2017 |
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All Science Journal Classification (ASJC) codes
- Physiology
- Molecular Biology
- Cell Biology
Cite this
}
Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota. / Li, Guolin; Xie, Cen; Lu, Siyu; Nichols, Robert G.; Tian, Yuan; Li, Licen; Patel, Daxeshkumar; Ma, Yinyan; Brocker, Chad N.; Yan, Tingting; Krausz, Kristopher W.; Xiang, Rong; Gavrilova, Oksana; Patterson, Andrew David; Gonzalez, Frank J.
In: Cell Metabolism, Vol. 26, No. 4, 03.10.2017, p. 672-685.e4.Research output: Contribution to journal › Article
TY - JOUR
T1 - Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
AU - Li, Guolin
AU - Xie, Cen
AU - Lu, Siyu
AU - Nichols, Robert G.
AU - Tian, Yuan
AU - Li, Licen
AU - Patel, Daxeshkumar
AU - Ma, Yinyan
AU - Brocker, Chad N.
AU - Yan, Tingting
AU - Krausz, Kristopher W.
AU - Xiang, Rong
AU - Gavrilova, Oksana
AU - Patterson, Andrew David
AU - Gonzalez, Frank J.
PY - 2017/10/3
Y1 - 2017/10/3
N2 - While activation of beige thermogenesis is a promising approach for treatment of obesity-associated diseases, there are currently no known pharmacological means of inducing beiging in humans. Intermittent fasting is an effective and natural strategy for weight control, but the mechanism for its efficacy is poorly understood. Here, we show that an every-other-day fasting (EODF) regimen selectively stimulates beige fat development within white adipose tissue and dramatically ameliorates obesity, insulin resistance, and hepatic steatosis. EODF treatment results in a shift in the gut microbiota composition leading to elevation of the fermentation products acetate and lactate and to the selective upregulation of monocarboxylate transporter 1 expression in beige cells. Microbiota-depleted mice are resistance to EODF-induced beiging, while transplantation of the microbiota from EODF-treated mice to microbiota-depleted mice activates beiging and improves metabolic homeostasis. These findings provide a new gut-microbiota-driven mechanism for activating adipose tissue browning and treating metabolic diseases. White adipose beiging is a promising therapy for obesity and related metabolic diseases. Here, Li, Xie and colleagues find that an EODF regimen can selectively induce the beiging of white adipose tissue and subsequently ameliorate metabolic disorders in mice. Gut microbiota orchestrate the effects of EODF on beiging and metabolic improvement.
AB - While activation of beige thermogenesis is a promising approach for treatment of obesity-associated diseases, there are currently no known pharmacological means of inducing beiging in humans. Intermittent fasting is an effective and natural strategy for weight control, but the mechanism for its efficacy is poorly understood. Here, we show that an every-other-day fasting (EODF) regimen selectively stimulates beige fat development within white adipose tissue and dramatically ameliorates obesity, insulin resistance, and hepatic steatosis. EODF treatment results in a shift in the gut microbiota composition leading to elevation of the fermentation products acetate and lactate and to the selective upregulation of monocarboxylate transporter 1 expression in beige cells. Microbiota-depleted mice are resistance to EODF-induced beiging, while transplantation of the microbiota from EODF-treated mice to microbiota-depleted mice activates beiging and improves metabolic homeostasis. These findings provide a new gut-microbiota-driven mechanism for activating adipose tissue browning and treating metabolic diseases. White adipose beiging is a promising therapy for obesity and related metabolic diseases. Here, Li, Xie and colleagues find that an EODF regimen can selectively induce the beiging of white adipose tissue and subsequently ameliorate metabolic disorders in mice. Gut microbiota orchestrate the effects of EODF on beiging and metabolic improvement.
UR - http://www.scopus.com/inward/record.url?scp=85029456215&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029456215&partnerID=8YFLogxK
U2 - 10.1016/j.cmet.2017.08.019
DO - 10.1016/j.cmet.2017.08.019
M3 - Article
C2 - 28918936
AN - SCOPUS:85029456215
VL - 26
SP - 672-685.e4
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
IS - 4
ER -