Internalizing symptoms associate with the pace of epigenetic aging in childhood

Marieke S. Tollenaar; Roseriet Beijers; Elika Garg; T. T.Thao Nguyen; David T.S. Lin; Julia L. MacIsaac; Idan Shalev; Michael S. Kobor; Michael J. Meaney; Kieran J. O'Donnell; Carolina de Weerth

doi:10.1016/j.biopsycho.2021.108021

Internalizing symptoms associate with the pace of epigenetic aging in childhood

Marieke S. Tollenaar, Roseriet Beijers, Elika Garg, T. T.Thao Nguyen, David T.S. Lin, Julia L. MacIsaac, Idan Shalev, Michael S. Kobor, Michael J. Meaney, Kieran J. O'Donnell, Carolina de Weerth

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Abstract

Childhood psychiatric symptoms may be associated with advanced biological aging. This study examined whether epigenetic age acceleration (EAA) associates with internalizing and externalizing symptoms that were prospectively collected across childhood in a longitudinal cohort study. At age 6 buccal epithelial cells from 148 children (69 girls) were collected to survey genome-wide DNA methylation. EAA was estimated using the Horvath clock. Internalizing symptoms at ages 2.5 and 4 years significantly predicted higher EAA at age 6, which in turn was significantly associated with internalizing symptoms at ages 6–10 years. Similar trends for externalizing symptoms did not reach statistical significance. These findings indicate advanced biological aging in relation to child mental health and may help better identify those at risk for lasting impairments associated with internalizing disorders.

Original language	English (US)
Article number	108021
Journal	Biological Psychology
Volume	159
DOIs	https://doi.org/10.1016/j.biopsycho.2021.108021
State	Published - Feb 2021

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Neuropsychology and Physiological Psychology

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10.1016/j.biopsycho.2021.108021

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title = "Internalizing symptoms associate with the pace of epigenetic aging in childhood",

abstract = "Childhood psychiatric symptoms may be associated with advanced biological aging. This study examined whether epigenetic age acceleration (EAA) associates with internalizing and externalizing symptoms that were prospectively collected across childhood in a longitudinal cohort study. At age 6 buccal epithelial cells from 148 children (69 girls) were collected to survey genome-wide DNA methylation. EAA was estimated using the Horvath clock. Internalizing symptoms at ages 2.5 and 4 years significantly predicted higher EAA at age 6, which in turn was significantly associated with internalizing symptoms at ages 6–10 years. Similar trends for externalizing symptoms did not reach statistical significance. These findings indicate advanced biological aging in relation to child mental health and may help better identify those at risk for lasting impairments associated with internalizing disorders.",

author = "Tollenaar, {Marieke S.} and Roseriet Beijers and Elika Garg and Nguyen, {T. T.Thao} and Lin, {David T.S.} and MacIsaac, {Julia L.} and Idan Shalev and Kobor, {Michael S.} and Meaney, {Michael J.} and O'Donnell, {Kieran J.} and {de Weerth}, Carolina",

note = "Funding Information: This research was supported by the Netherlands Organization for Scientific Research VENI grant 016.195.197 (RB), VIDI grant 575-25-009 (CdeW), and VICI grant 016.Vici.185.038 (CdeW), a Jacobs Foundation Advanced Research Fellowship (CdeW), and a Sara van Dam Project Grant of the Royal Netherlands Academy of Arts and Sciences (RB). IS was supported by the Mark T. Greenberg Early Career Professorship . KOD, MSK and MJM are CIFAR Fellows in the Child and Brain Development Program. Additional support came from the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development under Award Number P50HD089922, and the Canada First Research Excellence Fund: Healthy Brains for Healthy Lives . Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

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doi = "10.1016/j.biopsycho.2021.108021",

language = "English (US)",

volume = "159",

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T1 - Internalizing symptoms associate with the pace of epigenetic aging in childhood

AU - Tollenaar, Marieke S.

AU - Beijers, Roseriet

AU - Garg, Elika

AU - Nguyen, T. T.Thao

AU - Lin, David T.S.

AU - MacIsaac, Julia L.

AU - Shalev, Idan

AU - Kobor, Michael S.

AU - Meaney, Michael J.

AU - O'Donnell, Kieran J.

AU - de Weerth, Carolina

N1 - Funding Information: This research was supported by the Netherlands Organization for Scientific Research VENI grant 016.195.197 (RB), VIDI grant 575-25-009 (CdeW), and VICI grant 016.Vici.185.038 (CdeW), a Jacobs Foundation Advanced Research Fellowship (CdeW), and a Sara van Dam Project Grant of the Royal Netherlands Academy of Arts and Sciences (RB). IS was supported by the Mark T. Greenberg Early Career Professorship . KOD, MSK and MJM are CIFAR Fellows in the Child and Brain Development Program. Additional support came from the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development under Award Number P50HD089922, and the Canada First Research Excellence Fund: Healthy Brains for Healthy Lives . Publisher Copyright: © 2021 The Author(s)

PY - 2021/2

Y1 - 2021/2

N2 - Childhood psychiatric symptoms may be associated with advanced biological aging. This study examined whether epigenetic age acceleration (EAA) associates with internalizing and externalizing symptoms that were prospectively collected across childhood in a longitudinal cohort study. At age 6 buccal epithelial cells from 148 children (69 girls) were collected to survey genome-wide DNA methylation. EAA was estimated using the Horvath clock. Internalizing symptoms at ages 2.5 and 4 years significantly predicted higher EAA at age 6, which in turn was significantly associated with internalizing symptoms at ages 6–10 years. Similar trends for externalizing symptoms did not reach statistical significance. These findings indicate advanced biological aging in relation to child mental health and may help better identify those at risk for lasting impairments associated with internalizing disorders.

AB - Childhood psychiatric symptoms may be associated with advanced biological aging. This study examined whether epigenetic age acceleration (EAA) associates with internalizing and externalizing symptoms that were prospectively collected across childhood in a longitudinal cohort study. At age 6 buccal epithelial cells from 148 children (69 girls) were collected to survey genome-wide DNA methylation. EAA was estimated using the Horvath clock. Internalizing symptoms at ages 2.5 and 4 years significantly predicted higher EAA at age 6, which in turn was significantly associated with internalizing symptoms at ages 6–10 years. Similar trends for externalizing symptoms did not reach statistical significance. These findings indicate advanced biological aging in relation to child mental health and may help better identify those at risk for lasting impairments associated with internalizing disorders.

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Internalizing symptoms associate with the pace of epigenetic aging in childhood

Abstract

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