Interpersonal pathoplasticity in the course of major depression

Nicole M. Cain, Emily B. Ansell, Aidan G.C. Wright, Christopher J. Hopwood, Katherine M. Thomas, Anthony Pinto, John C. Markowitz, Charles A. Sanislow, Mary C. Zanarini, M. Tracie Shea, Leslie C. Morey, Thomas H. McGlashan, Andrew E. Skodol, Carlos M. Grilo

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Objective: The identification of reliable predictors of course in major depressive disorder (MDD) has been difficult. Evidence suggests that the co-occurrence of personality pathology is associated with longer time to MDD remission. Interpersonal pathoplasticity, the mutually influencing nonetiological relationship between psychopathology and interpersonal traits, offers an avenue for examining specific personality vulnerabilities that may be associated with depressive course. Method: This study examined 312 participants with and without a co-occurring personality disorder diagnosis who met criteria for a current MDD episode at baseline and who were followed for 10 years in the Collaborative Longitudinal Personality Disorders Study. Results: Latent profile analysis (LPA) identified 6 interpersonal groups (extraverted, dominant, arrogant, cold, submissive, and unassuming), and circular statistical profile analysis confirmed group interpersonal distinctiveness. No significant differences between groups were found in comorbid Axis I disorders or baseline MDD severity. Chronicity and functioning analyses found significantly greater chronicity and poorer functioning in individuals with a submissive interpersonal style over 10 years. Conclusions: These findings support the relevance of interpersonal pathoplasticity in depressive course and that this heterogeneity has clinical significance. This study is the first to use LPA and circular profiles to examine interpersonal heterogeneity within a diagnostic group. The implications of these findings for therapeutic intervention, interpersonal functioning, and psychopathological course are discussed.

Original languageEnglish (US)
Pages (from-to)78-86
Number of pages9
JournalJournal of consulting and clinical psychology
Volume80
Issue number1
DOIs
StatePublished - Feb 1 2012

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Major Depressive Disorder
Depression
Personality Disorders
Personality
Psychopathology
Pathology
Therapeutics

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Cain, N. M., Ansell, E. B., Wright, A. G. C., Hopwood, C. J., Thomas, K. M., Pinto, A., ... Grilo, C. M. (2012). Interpersonal pathoplasticity in the course of major depression. Journal of consulting and clinical psychology, 80(1), 78-86. https://doi.org/10.1037/a0026433
Cain, Nicole M. ; Ansell, Emily B. ; Wright, Aidan G.C. ; Hopwood, Christopher J. ; Thomas, Katherine M. ; Pinto, Anthony ; Markowitz, John C. ; Sanislow, Charles A. ; Zanarini, Mary C. ; Shea, M. Tracie ; Morey, Leslie C. ; McGlashan, Thomas H. ; Skodol, Andrew E. ; Grilo, Carlos M. / Interpersonal pathoplasticity in the course of major depression. In: Journal of consulting and clinical psychology. 2012 ; Vol. 80, No. 1. pp. 78-86.
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Cain, NM, Ansell, EB, Wright, AGC, Hopwood, CJ, Thomas, KM, Pinto, A, Markowitz, JC, Sanislow, CA, Zanarini, MC, Shea, MT, Morey, LC, McGlashan, TH, Skodol, AE & Grilo, CM 2012, 'Interpersonal pathoplasticity in the course of major depression', Journal of consulting and clinical psychology, vol. 80, no. 1, pp. 78-86. https://doi.org/10.1037/a0026433

Interpersonal pathoplasticity in the course of major depression. / Cain, Nicole M.; Ansell, Emily B.; Wright, Aidan G.C.; Hopwood, Christopher J.; Thomas, Katherine M.; Pinto, Anthony; Markowitz, John C.; Sanislow, Charles A.; Zanarini, Mary C.; Shea, M. Tracie; Morey, Leslie C.; McGlashan, Thomas H.; Skodol, Andrew E.; Grilo, Carlos M.

In: Journal of consulting and clinical psychology, Vol. 80, No. 1, 01.02.2012, p. 78-86.

Research output: Contribution to journalArticle

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T1 - Interpersonal pathoplasticity in the course of major depression

AU - Cain, Nicole M.

AU - Ansell, Emily B.

AU - Wright, Aidan G.C.

AU - Hopwood, Christopher J.

AU - Thomas, Katherine M.

AU - Pinto, Anthony

AU - Markowitz, John C.

AU - Sanislow, Charles A.

AU - Zanarini, Mary C.

AU - Shea, M. Tracie

AU - Morey, Leslie C.

AU - McGlashan, Thomas H.

AU - Skodol, Andrew E.

AU - Grilo, Carlos M.

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Objective: The identification of reliable predictors of course in major depressive disorder (MDD) has been difficult. Evidence suggests that the co-occurrence of personality pathology is associated with longer time to MDD remission. Interpersonal pathoplasticity, the mutually influencing nonetiological relationship between psychopathology and interpersonal traits, offers an avenue for examining specific personality vulnerabilities that may be associated with depressive course. Method: This study examined 312 participants with and without a co-occurring personality disorder diagnosis who met criteria for a current MDD episode at baseline and who were followed for 10 years in the Collaborative Longitudinal Personality Disorders Study. Results: Latent profile analysis (LPA) identified 6 interpersonal groups (extraverted, dominant, arrogant, cold, submissive, and unassuming), and circular statistical profile analysis confirmed group interpersonal distinctiveness. No significant differences between groups were found in comorbid Axis I disorders or baseline MDD severity. Chronicity and functioning analyses found significantly greater chronicity and poorer functioning in individuals with a submissive interpersonal style over 10 years. Conclusions: These findings support the relevance of interpersonal pathoplasticity in depressive course and that this heterogeneity has clinical significance. This study is the first to use LPA and circular profiles to examine interpersonal heterogeneity within a diagnostic group. The implications of these findings for therapeutic intervention, interpersonal functioning, and psychopathological course are discussed.

AB - Objective: The identification of reliable predictors of course in major depressive disorder (MDD) has been difficult. Evidence suggests that the co-occurrence of personality pathology is associated with longer time to MDD remission. Interpersonal pathoplasticity, the mutually influencing nonetiological relationship between psychopathology and interpersonal traits, offers an avenue for examining specific personality vulnerabilities that may be associated with depressive course. Method: This study examined 312 participants with and without a co-occurring personality disorder diagnosis who met criteria for a current MDD episode at baseline and who were followed for 10 years in the Collaborative Longitudinal Personality Disorders Study. Results: Latent profile analysis (LPA) identified 6 interpersonal groups (extraverted, dominant, arrogant, cold, submissive, and unassuming), and circular statistical profile analysis confirmed group interpersonal distinctiveness. No significant differences between groups were found in comorbid Axis I disorders or baseline MDD severity. Chronicity and functioning analyses found significantly greater chronicity and poorer functioning in individuals with a submissive interpersonal style over 10 years. Conclusions: These findings support the relevance of interpersonal pathoplasticity in depressive course and that this heterogeneity has clinical significance. This study is the first to use LPA and circular profiles to examine interpersonal heterogeneity within a diagnostic group. The implications of these findings for therapeutic intervention, interpersonal functioning, and psychopathological course are discussed.

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