Interplay between calcium and reactive Oxygen/Nitrogen species: An essential paradigm for vascular smooth muscle signaling

Mohamed Trebak, Roman Ginnan, Harold A. Singer, David Jourd'Heuil

Research output: Contribution to journalReview article

73 Scopus citations


Signaling cascades initiated or regulated by calcium (Ca2+), reactive oxygen (ROS), and nitrogen (RNS) species are essential to diverse physiological and pathological processes in vascular smooth muscle. Stimuli-induced changes in intracellular Ca2+ regulate the activity of primary ROS and RNS, producing enzymes including NADPH oxidases (Nox) and nitric oxide synthases (NOS). At the same time, alteration in intracellular ROS and RNS production reciprocates through redox-based post-translational modifications altering Ca2+ signaling networks. These may include Ca2+ pumps such as sarcoplasmic endoplasmic reticulum Ca 2+-ATPase (SERCA), voltage-gated channels, transient receptor potential canonical (TRPC), melastatin2 (TRPM2), and ankyrin1 (TRPA1) channels, store operated Ca2+ channels such as Orai1/stromal interaction molecule 1 (STIM1), and Ca2+ effectors such as Ca2+/ calmodulin-dependent protein kinase II (CaMKII). In this review, we summarize and highlight current experimental evidence supporting the idea that cross-talk between Ca2+ and ROS/RNS may represent a well-integrated signaling network in vascular smooth muscle. Antioxid.

Original languageEnglish (US)
Pages (from-to)657-674
Number of pages18
JournalAntioxidants and Redox Signaling
Issue number5
StatePublished - Mar 1 2010


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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