Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats

Narasimha V. Hegde, Erica L. Unger, Gordon Lee Jensen, Pamela Hankey Giblin, Robert Paulson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Dietary iron is particularly critical during periods of rapid growth such as in neonatal development. Human and rodent studies have indicated that iron deficiency or excess during this critical stage of development can have significant long- and short-term consequences. Since the requirement for iron changes during development, the availability of adequate iron is critical for the differentiation and maturation of individual organs participating in iron homeostasis. We have examined in rats the effects of dietary iron supplement following neonatal iron deficiency on tissue iron status in relation to erythropoietic ability during 16 wk of postweaning development. This physiological model indicates that postweaning iron-adequate diet following neonatal iron deficiency adversely affects erythroid differentiation in the bone marrow and promotes splenic erythropoiesis leading to splenomegaly and erythrocytosis. This altered physiology of iron homeostasis during postweaning development is also reflected in the inability to maintain liver and spleen iron concentrations and the altered expression of iron regulatory proteins in the liver. These studies provide critical insights into the consequences of neonatal iron deficiency and the dietary iron-induced cellular signals affecting iron homeostasis during early development.

Original languageEnglish (US)
Pages (from-to)470-476
Number of pages7
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume300
Issue number3
DOIs
StatePublished - Mar 1 2011

Fingerprint

Erythropoiesis
Iron
Dietary Iron
Homeostasis
Iron-Regulatory Proteins
Polycythemia
Liver
Splenomegaly
Dietary Supplements
Rodentia
Spleen
Bone Marrow

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Physiology (medical)
  • Physiology
  • Hepatology

Cite this

@article{8eac1f7748bb4e1fbd92f8c9c45db595,
title = "Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats",
abstract = "Dietary iron is particularly critical during periods of rapid growth such as in neonatal development. Human and rodent studies have indicated that iron deficiency or excess during this critical stage of development can have significant long- and short-term consequences. Since the requirement for iron changes during development, the availability of adequate iron is critical for the differentiation and maturation of individual organs participating in iron homeostasis. We have examined in rats the effects of dietary iron supplement following neonatal iron deficiency on tissue iron status in relation to erythropoietic ability during 16 wk of postweaning development. This physiological model indicates that postweaning iron-adequate diet following neonatal iron deficiency adversely affects erythroid differentiation in the bone marrow and promotes splenic erythropoiesis leading to splenomegaly and erythrocytosis. This altered physiology of iron homeostasis during postweaning development is also reflected in the inability to maintain liver and spleen iron concentrations and the altered expression of iron regulatory proteins in the liver. These studies provide critical insights into the consequences of neonatal iron deficiency and the dietary iron-induced cellular signals affecting iron homeostasis during early development.",
author = "Hegde, {Narasimha V.} and Unger, {Erica L.} and Jensen, {Gordon Lee} and Giblin, {Pamela Hankey} and Robert Paulson",
year = "2011",
month = "3",
day = "1",
doi = "10.1152/ajpgi.00463.2010",
language = "English (US)",
volume = "300",
pages = "470--476",
journal = "American Journal of Physiology - Endocrinology and Metabolism",
issn = "0193-1849",
publisher = "American Physiological Society",
number = "3",

}

TY - JOUR

T1 - Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats

AU - Hegde, Narasimha V.

AU - Unger, Erica L.

AU - Jensen, Gordon Lee

AU - Giblin, Pamela Hankey

AU - Paulson, Robert

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Dietary iron is particularly critical during periods of rapid growth such as in neonatal development. Human and rodent studies have indicated that iron deficiency or excess during this critical stage of development can have significant long- and short-term consequences. Since the requirement for iron changes during development, the availability of adequate iron is critical for the differentiation and maturation of individual organs participating in iron homeostasis. We have examined in rats the effects of dietary iron supplement following neonatal iron deficiency on tissue iron status in relation to erythropoietic ability during 16 wk of postweaning development. This physiological model indicates that postweaning iron-adequate diet following neonatal iron deficiency adversely affects erythroid differentiation in the bone marrow and promotes splenic erythropoiesis leading to splenomegaly and erythrocytosis. This altered physiology of iron homeostasis during postweaning development is also reflected in the inability to maintain liver and spleen iron concentrations and the altered expression of iron regulatory proteins in the liver. These studies provide critical insights into the consequences of neonatal iron deficiency and the dietary iron-induced cellular signals affecting iron homeostasis during early development.

AB - Dietary iron is particularly critical during periods of rapid growth such as in neonatal development. Human and rodent studies have indicated that iron deficiency or excess during this critical stage of development can have significant long- and short-term consequences. Since the requirement for iron changes during development, the availability of adequate iron is critical for the differentiation and maturation of individual organs participating in iron homeostasis. We have examined in rats the effects of dietary iron supplement following neonatal iron deficiency on tissue iron status in relation to erythropoietic ability during 16 wk of postweaning development. This physiological model indicates that postweaning iron-adequate diet following neonatal iron deficiency adversely affects erythroid differentiation in the bone marrow and promotes splenic erythropoiesis leading to splenomegaly and erythrocytosis. This altered physiology of iron homeostasis during postweaning development is also reflected in the inability to maintain liver and spleen iron concentrations and the altered expression of iron regulatory proteins in the liver. These studies provide critical insights into the consequences of neonatal iron deficiency and the dietary iron-induced cellular signals affecting iron homeostasis during early development.

UR - http://www.scopus.com/inward/record.url?scp=79954528758&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954528758&partnerID=8YFLogxK

U2 - 10.1152/ajpgi.00463.2010

DO - 10.1152/ajpgi.00463.2010

M3 - Article

VL - 300

SP - 470

EP - 476

JO - American Journal of Physiology - Endocrinology and Metabolism

JF - American Journal of Physiology - Endocrinology and Metabolism

SN - 0193-1849

IS - 3

ER -