Abstract
Traditionally, signaling pathways have been perceived to act in an autonomous manner to regulate tissue morphology, size, differentiation, and development. Recent evidence suggests that these pathways often intersect and regulate one another to elicit an appropriate response to a complex set of stimuli. Two pathways known to be important for development, growth, and homeostasis are the Wnt/b-catenin and the Hippo/YAP pathways. Growing data indicate that these two pathways influence each other in a number of ways to properly regulate tissue growth and repair. Deregulation of these pathways often contributes to tumorigenesis. In this review, we will discuss the points of intersection between the Wnt/β-catenin and Hippo/YAP pathways and how these interactions contribute to homeostasis, organ repair, and tumorigenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 71-79 |
| Number of pages | 9 |
| Journal | Acta Biochimica et Biophysica Sinica |
| Volume | 45 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2013 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Biophysics
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Intersection of Hippo/YAP and Wnt/β-catenin signaling pathways. / Konsavage, Wesley M.; Yochum, Gregory S.
In: Acta Biochimica et Biophysica Sinica, Vol. 45, No. 2, 01.01.2013, p. 71-79.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Intersection of Hippo/YAP and Wnt/β-catenin signaling pathways
AU - Konsavage, Wesley M.
AU - Yochum, Gregory S.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Traditionally, signaling pathways have been perceived to act in an autonomous manner to regulate tissue morphology, size, differentiation, and development. Recent evidence suggests that these pathways often intersect and regulate one another to elicit an appropriate response to a complex set of stimuli. Two pathways known to be important for development, growth, and homeostasis are the Wnt/b-catenin and the Hippo/YAP pathways. Growing data indicate that these two pathways influence each other in a number of ways to properly regulate tissue growth and repair. Deregulation of these pathways often contributes to tumorigenesis. In this review, we will discuss the points of intersection between the Wnt/β-catenin and Hippo/YAP pathways and how these interactions contribute to homeostasis, organ repair, and tumorigenesis.
AB - Traditionally, signaling pathways have been perceived to act in an autonomous manner to regulate tissue morphology, size, differentiation, and development. Recent evidence suggests that these pathways often intersect and regulate one another to elicit an appropriate response to a complex set of stimuli. Two pathways known to be important for development, growth, and homeostasis are the Wnt/b-catenin and the Hippo/YAP pathways. Growing data indicate that these two pathways influence each other in a number of ways to properly regulate tissue growth and repair. Deregulation of these pathways often contributes to tumorigenesis. In this review, we will discuss the points of intersection between the Wnt/β-catenin and Hippo/YAP pathways and how these interactions contribute to homeostasis, organ repair, and tumorigenesis.
UR - http://www.scopus.com/inward/record.url?scp=84881239237&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881239237&partnerID=8YFLogxK
U2 - 10.1093/abbs/gms084
DO - 10.1093/abbs/gms084
M3 - Review article
C2 - 23027379
AN - SCOPUS:84881239237
VL - 45
SP - 71
EP - 79
JO - Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica
JF - Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica
SN - 1672-9145
IS - 2
ER -