Intersection of Hippo/YAP and Wnt/β-catenin signaling pathways

Wesley M. Konsavage, Gregory S. Yochum

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Traditionally, signaling pathways have been perceived to act in an autonomous manner to regulate tissue morphology, size, differentiation, and development. Recent evidence suggests that these pathways often intersect and regulate one another to elicit an appropriate response to a complex set of stimuli. Two pathways known to be important for development, growth, and homeostasis are the Wnt/b-catenin and the Hippo/YAP pathways. Growing data indicate that these two pathways influence each other in a number of ways to properly regulate tissue growth and repair. Deregulation of these pathways often contributes to tumorigenesis. In this review, we will discuss the points of intersection between the Wnt/β-catenin and Hippo/YAP pathways and how these interactions contribute to homeostasis, organ repair, and tumorigenesis.

Original languageEnglish (US)
Pages (from-to)71-79
Number of pages9
JournalActa Biochimica et Biophysica Sinica
Volume45
Issue number2
DOIs
StatePublished - Jan 1 2013

Fingerprint

Catenins
Wnt Signaling Pathway
Carcinogenesis
Homeostasis
Repair
Tissue
Deregulation
Growth and Development
Growth

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics

Cite this

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Intersection of Hippo/YAP and Wnt/β-catenin signaling pathways. / Konsavage, Wesley M.; Yochum, Gregory S.

In: Acta Biochimica et Biophysica Sinica, Vol. 45, No. 2, 01.01.2013, p. 71-79.

Research output: Contribution to journalReview article

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